Oral Hyperglycaemic Drugs Flashcards
1
Q
DMII can’t have what after a meal?
A
insulin burst
2
Q
First DM2 drugs were?
A
sulphonamide drugs
3
Q
Mechanism of Sulphonylureas?
A
Inhibit K-ATP channel to cause insulin secretion
4
Q
Sulphonylureas preg? excretion?
A
Not in preg
excreted in kidney
5
Q
Sulphonylureas weight gain or loss?
A
gain
6
Q
3 actions of insulin
A
GLUT 4
PI3-kinase
SHC
7
Q
What is Guanidine?
A
from french lilac later isolated and medicinalized to Biguanides
8
Q
What is the most used Biguanides?
A
Metformin
9
Q
4 Metformin actions:
A
- increase glucose uptake
- reduce hepatic glucose production
- decrease carb absorption
- reduce LDL
10
Q
What is Metformin’s MOA?
A
activate AMP kinase
11
Q
Sulphonylureas weight gain or loss?
A
some loss
12
Q
Metformin contraindication?
A
impaired renal function?
13
Q
Metformin is a?
A
Biguanide
14
Q
What drugs stims insulin?
A
Sulfonylureas
meglitinides
15
Q
What drugs sensitize body to insulin?
A
Biguanides
thiazolidinediones
