Drugs used in Obesity Flashcards
What are 2 Satiety signals?
- CCK
2. Liver Sympathetic
What are 2 adiposity signals?
Leptin
Insulin
What is orexigenic? Example?
increase feeding
Neuropeptide Y
What is anorexigenic mean? Example?
decrease feeding
alpha-melanocyte stimulating hormone
Both Neuropeptide Y and a-melanocyte stimulating hormone act peripherally or centrally?
centrally
4 peripheral peptides that regulate eating?
Ghrelin
Leptin
Insulin
CCK
Leptin higher or lower at what time of day?
peaks at lunch
nadir at midnight
Leptin crosses BBB how?
actively transported
Why is leptin not a good magic pill?
leptin transport is saturable process, so perhaps can’t get enough in
leptin receptors are where?
hypothalamus
leptin levels in obese people are?
high
Leptin resistance can happen where? 3 places
- Hypothalamus receptors
- 2nd messenger
- saturated leptin transport system
Target what 2 things in fat for obesity? which drugs?
absorption - orlistat
metabolism - lipolysis
B3 adrenergic receptor agonists do what?
increase thermogenesis
How does Phentermine work?
sympathomimetic amine
How long use phentermine for?
3 weeks only
how long use orlistat for?
long term use
Obesity drugs need to be combined with?
low calorie diet
exercise
what does phentermine do to the brain?
increases NA, DA, 5-HT
mechanism of phentermine on neurons?
inhibit neuronal uptake
phentermine cannot be combined with?
MAO inhibitors
pregnancy
Topiramate main 2 uses? off-label?
epilepsy, migraine
off-label: weight loss
When to take Orlistat during day?
before meals
orlistate mechanism?
bind and block lipase, prevent fat absorption
