Drugs used in Obesity

Question 0

What are 2 Satiety signals?

Answer 0

1. CCK

2. Liver Sympathetic

Question 1

What are 2 adiposity signals?

Answer 1

Leptin

Insulin

Question 2

What is orexigenic? Example?

Answer 2

increase feeding

Neuropeptide Y

Question 3

What is anorexigenic mean? Example?

Answer 3

decrease feeding

alpha-melanocyte stimulating hormone

Question 4

Both Neuropeptide Y and a-melanocyte stimulating hormone act peripherally or centrally?

Answer 4

centrally

Question 5

4 peripheral peptides that regulate eating?

Answer 5

Ghrelin
Leptin
Insulin
CCK

Question 6

Leptin higher or lower at what time of day?

Answer 6

peaks at lunch

nadir at midnight

Question 7

Leptin crosses BBB how?

Answer 7

actively transported

Question 8

Why is leptin not a good magic pill?

Answer 8

leptin transport is saturable process, so perhaps can’t get enough in

Question 9

leptin receptors are where?

Answer 9

hypothalamus

Question 10

leptin levels in obese people are?

Answer 10

high

Question 11

Leptin resistance can happen where? 3 places

Answer 11

1. Hypothalamus receptors
2. 2nd messenger
3. saturated leptin transport system

Question 12

Target what 2 things in fat for obesity? which drugs?

Answer 12

absorption - orlistat

metabolism - lipolysis

Question 13

B3 adrenergic receptor agonists do what?

Answer 13

increase thermogenesis

Question 14

How does Phentermine work?

Answer 14

sympathomimetic amine

Question 15

How long use phentermine for?

Answer 15

3 weeks only

Question 16

how long use orlistat for?

Answer 16

long term use

Question 17

Obesity drugs need to be combined with?

Answer 17

low calorie diet

exercise

Question 18

what does phentermine do to the brain?

Answer 18

increases NA, DA, 5-HT

Question 19

mechanism of phentermine on neurons?

Answer 19

inhibit neuronal uptake

Question 20

phentermine cannot be combined with?

Answer 20

MAO inhibitors

pregnancy

Question 21

Topiramate main 2 uses? off-label?

Answer 21

epilepsy, migraine

off-label: weight loss

Question 22

When to take Orlistat during day?

Answer 22

before meals

Question 23

orlistate mechanism?

Answer 23

bind and block lipase, prevent fat absorption

Question 24

why would orlistat help people change their diet and lose weight?

Answer 24

side effects if have fatty meal is faecal fat leakage and explosive diarrhoea

Question 25

supplementation with orlistat?

Answer 25

yes D & E

Question 26

why only use phentermine for short term?

Answer 26

tolerance

addiction