Oncology: SE Medications Flashcards
1
Q
Neupogen
A
- Filgrastim
- CSF
- Injected QD (IV/SQ)
2
Q
Neulasta
A
- Pegfilgrastim
- Pegylated CSF
- Administered SQ once per chemo cycle
3
Q
CSF Information
A
- SE: Bone pain
- More severe SE in sargramostim (limited to stem cell transplantation)
- Store in fridge
- Report any signs of enlarged spleen (pain in upper, left abdomen)
- Document when pegfilgrastim is given (min. of 12 days between administrations)
4
Q
Procrit
A
- Epoetin Alfa
- AKA Epogen
- ESA for anemia in NON-curative cancer
5
Q
Aranesp
A
- Darbepoetin alfa
- ESA for anemia in NON-curative cancer
6
Q
NK1-RA Examples
A
- Aprepitant PO
- Dosaprepitant IV
- Rolapitant
7
Q
Akynzeo (PO)
A
-Netupitant/palonosetron PO
8
Q
Akynzeo (IV)
A
-Fosnetupitant/palonosetron IV
9
Q
Emend (PO)
A
- Aprepitant
- NK1-RA
- Inhibits acute and delayed CINV
- Decrease dexamethasone dose if used concurrently, CYP3A4i
10
Q
Emend (IV)
A
- Fosaprepitant
- NK1-RA
- Inhibits acute/delayed phases of CINV
- Decrease dexamethasone dose if used concurrently, CYP3A4i
11
Q
Zuplenz
A
- Ondansetron, film formulation
- 5HT3-RA
- Can be given day 1 of chemo
12
Q
Sancruso
A
- Granisetron
- 5HT3-RA
- Patch: apply 24-48 hours BEFORE chemo
13
Q
Aloxi
A
- Palonosetron
- 5HT3-RA
- Can be given day 1 of chemo
14
Q
Dolasetron
A
- 5HT3-RA NOT indicated for CINV
- Increases risk for QT prolongation
15
Q
5HT3-RA Information
A
- CI: Do not use with apomorphine (severe HTN/loss of consciousness)
- Increases QT interval based on dose, 5HT syndrome risk
- SE: HA, constipation
16
Q
Decadrone
A
- Dexamethasone
- Used for CINV
- Short-term SE: weight gain, fluid retention, insomnia, increase BG/BP (high doses)
17
Q
Dopamine Receptor Antagonists Examples
A
Block dopamine receptors in CNS including chemoreceptor trigger zone:
- Prochlorperazine
- Promethazine
- Metoclopramide
- Olanzapine
18
Q
Compazine
A
- Prochlorperazine
- Dopamine receptor antagonists
- Don’t give in kids < 2 yo
- Do not give intra-arterial or SQ
- IV can cause serious tissue injury if extravasation occurs
19
Q
Phenergan
A
- Promethazine
- Dopamine receptor antagonist
- Tardive dyskinesia can be irreversible
20
Q
Droperidol
A
- Dopamine receptor antagonist NOT indicated for CINV
- Can cause QT prolongation and serious arrhythmias
21
Q
Reglan
A
- Metoclopramide
- Dopamine receptor antagonist
22
Q
Zyprexa
A
- Olanzapine
- Dopamine receptor antagonist
23
Q
Dopamine Receptor Antagonists SE
A
- Sedation
- Lethargy
- Acute EPS
- Decreased seizure threshold
24
Q
Marinol
A
- Dronadinol
- Cannabinoid used second-line for nausea control
- Refrigerate
- SE: Somnolence, euphoria, increased appetite
- CII or CIII depending on formulation
25
Q
Cesamet
A
- Nabilone
- Cannabinoid used second-line for nausea control
- SE: Somnolence, euphoria, increased appetite
- CII
26
Q
Ativan
A
- Lorazepam
- BZD, enhances GABA, used for anticipatory CINV
- Start evening PRIOR to chemo
27
Q
Miacalcin
A
- Calcitonin
- Inhibits bone resorption and increases kidney Ca excretion
- Used initially for hypercalcemia of malignancy tx in mod-severe symptomatic pts
28
Q
Zometa
A
- IV bisphosphonate used for hypercalcemia of malignancy tx in mod-severe symptomatic pts
- Do not use with Reclast (dosed yearly for osteoporosis)
29
Q
Xgeva
A
- Monoclonal antibody that blocks interaction between RANKL and RANK
- Used as an alternative to IV bisphosphonates
- Don’t use with Prolia (dosed Q6mo for osteoporosis)
30
Q
Drugs Administered Intrathecally
A
- MTX
- Hydrocortisone
- Thiotepa
- Cytarabine
- *ALL must be preservative free**
