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naplex > Oncology: SE Medications > Flashcards

Oncology: SE Medications Flashcards

1
Q

Neupogen

A
  • Filgrastim
  • CSF
  • Injected QD (IV/SQ)
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2
Q

Neulasta

A
  • Pegfilgrastim
  • Pegylated CSF
  • Administered SQ once per chemo cycle
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3
Q

CSF Information

A
  • SE: Bone pain
  • More severe SE in sargramostim (limited to stem cell transplantation)
  • Store in fridge
  • Report any signs of enlarged spleen (pain in upper, left abdomen)
  • Document when pegfilgrastim is given (min. of 12 days between administrations)
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4
Q

Procrit

A
  • Epoetin Alfa
  • AKA Epogen
  • ESA for anemia in NON-curative cancer
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5
Q

Aranesp

A
  • Darbepoetin alfa

- ESA for anemia in NON-curative cancer

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6
Q

NK1-RA Examples

A
  • Aprepitant PO
  • Dosaprepitant IV
  • Rolapitant
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7
Q

Akynzeo (PO)

A

-Netupitant/palonosetron PO

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8
Q

Akynzeo (IV)

A

-Fosnetupitant/palonosetron IV

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9
Q

Emend (PO)

A
  • Aprepitant
  • NK1-RA
  • Inhibits acute and delayed CINV
  • Decrease dexamethasone dose if used concurrently, CYP3A4i
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10
Q

Emend (IV)

A
  • Fosaprepitant
  • NK1-RA
  • Inhibits acute/delayed phases of CINV
  • Decrease dexamethasone dose if used concurrently, CYP3A4i
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11
Q

Zuplenz

A
  • Ondansetron, film formulation
  • 5HT3-RA
  • Can be given day 1 of chemo
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12
Q

Sancruso

A
  • Granisetron
  • 5HT3-RA
  • Patch: apply 24-48 hours BEFORE chemo
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13
Q

Aloxi

A
  • Palonosetron
  • 5HT3-RA
  • Can be given day 1 of chemo
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14
Q

Dolasetron

A
  • 5HT3-RA NOT indicated for CINV

- Increases risk for QT prolongation

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15
Q

5HT3-RA Information

A
  • CI: Do not use with apomorphine (severe HTN/loss of consciousness)
  • Increases QT interval based on dose, 5HT syndrome risk
  • SE: HA, constipation
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16
Q

Decadrone

A
  • Dexamethasone
  • Used for CINV
  • Short-term SE: weight gain, fluid retention, insomnia, increase BG/BP (high doses)
17
Q

Dopamine Receptor Antagonists Examples

A

Block dopamine receptors in CNS including chemoreceptor trigger zone:

  • Prochlorperazine
  • Promethazine
  • Metoclopramide
  • Olanzapine
18
Q

Compazine

A
  • Prochlorperazine
  • Dopamine receptor antagonists
  • Don’t give in kids < 2 yo
  • Do not give intra-arterial or SQ
  • IV can cause serious tissue injury if extravasation occurs
19
Q

Phenergan

A
  • Promethazine
  • Dopamine receptor antagonist
  • Tardive dyskinesia can be irreversible
20
Q

Droperidol

A
  • Dopamine receptor antagonist NOT indicated for CINV

- Can cause QT prolongation and serious arrhythmias

21
Q

Reglan

A
  • Metoclopramide

- Dopamine receptor antagonist

22
Q

Zyprexa

A
  • Olanzapine

- Dopamine receptor antagonist

23
Q

Dopamine Receptor Antagonists SE

A
  • Sedation
  • Lethargy
  • Acute EPS
  • Decreased seizure threshold
24
Q

Marinol

A
  • Dronadinol
  • Cannabinoid used second-line for nausea control
  • Refrigerate
  • SE: Somnolence, euphoria, increased appetite
  • CII or CIII depending on formulation
25
Q

Cesamet

A
  • Nabilone
  • Cannabinoid used second-line for nausea control
  • SE: Somnolence, euphoria, increased appetite
  • CII
26
Q

Ativan

A
  • Lorazepam
  • BZD, enhances GABA, used for anticipatory CINV
  • Start evening PRIOR to chemo
27
Q

Miacalcin

A
  • Calcitonin
  • Inhibits bone resorption and increases kidney Ca excretion
  • Used initially for hypercalcemia of malignancy tx in mod-severe symptomatic pts
28
Q

Zometa

A
  • IV bisphosphonate used for hypercalcemia of malignancy tx in mod-severe symptomatic pts
  • Do not use with Reclast (dosed yearly for osteoporosis)
29
Q

Xgeva

A
  • Monoclonal antibody that blocks interaction between RANKL and RANK
  • Used as an alternative to IV bisphosphonates
  • Don’t use with Prolia (dosed Q6mo for osteoporosis)
30
Q

Drugs Administered Intrathecally

A
  • MTX
  • Hydrocortisone
  • Thiotepa
  • Cytarabine
  • *ALL must be preservative free**

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