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Phase 3b/finals > Oncology > Flashcards

Oncology Flashcards

1
Q

How do alkylating agents work?

A

Bind to DNA, forming crosslinks and preventing replication

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2
Q

Give 2 examples of alykylating agents

A

cisplatin

cyclophosphamide

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3
Q

Give an example of an antimetabolite

A

Methotrexate

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4
Q

How do antimetabolites work?

A

Interrupting normal metabolism of nucleic acids

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5
Q

CA-125 is the tumour marker for?

A

Ocarian cancer

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6
Q

What is the tumour marker for pancreatic cancer?

A

CA 19-9

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7
Q

What is the tumour marker for breast cancer?

A

CA 15-3

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8
Q

CEA is a tumour marker for?

A

Colorectal cancer

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9
Q

Raised AFP and beta hCG indicates?

A

Non-seminomatous testicular cancer

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10
Q

Raised AFP in an older woman indicates?

A

Liver cancer

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11
Q

What cancer would you worry about in a patient with painless jaundice?

A

Pancreatic

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12
Q

What is the breakthrough pain dosage?

A

1/6th of the daily dosage

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13
Q

How would you treat metastatic bone pain?

A

Analgesia, bisphosphonates and radiotherapy

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14
Q

How should opioid dosage be increased?

A

By 30-50%

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15
Q

Which type of cancer has the strongest association with smoking?

A

Squamous cell lung carcinoma

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16
Q

Oral morphine to subcut diamorphine conversion:

A

Divide by 3

17
Q

Oral morphine to subcut morphine conversion:

A

Divide by 2

18
Q

Oral morphine to oral oxycodone conversion:

A

Divide by 1.5-2

19
Q

Oral codeine or tramadol to oral morphine conversion rate:

A

Divide by 10

20
Q

What would you put in the syringe driver for respiratory secretions?

A

Hyoscine hydrobromide

21
Q

What would you put in the syringe driver for bowel colic?

A

Hyoscine butylbromide

22
Q

What would you put in the syringe driver for nausea and vomitinG?

23
Q

What would you put in the syringe driver for agitation?

A

Midazolam, haloperifol

24
Q

What would you put in the syringe driver for pain?

A

Diamorphine

25
Q

What is the first line treatment for chemotherapy induced nausea?

A

Metoclopramide

26
Q

What is the 2nd line treatment for chemotherapy induced nausea?

A

Ondansetron and dexamethasone

27
Q

What type of drug is ondansetron?

A

5HT3 antagonist

28
Q

What kind of lung cancer do non smokers get?

A

Adenocarcinoma

29
Q

What would you prescribe for headaches and nausea caused by raiced ICP due to mets?

A

Dexamethasone

30
Q

What’s a tumour marker for medullary thyroid cancer?

A

Calcitonin

31
Q

What type of cancer is thyroglobulin a tumour marker for?

A

Follicular or papillary thyroid cancer

32
Q

Which chemotherapy drugs cause peripheral neuropathy?

A

Vincristine, cisplatin

33
Q

Which chemo drugs cause cardiomyopathy?

A

Doxorubacin

34
Q

Which drug may cause lung fibrosis?

Phase 3b/finals (19 decks)

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