Oncology

Question 1

How do alkylating agents work?

Answer 1

Bind to DNA, forming crosslinks and preventing replication

Question 2

Give 2 examples of alykylating agents

Answer 2

cisplatin

cyclophosphamide

Question 3

Give an example of an antimetabolite

Answer 3

Methotrexate

Question 4

How do antimetabolites work?

Answer 4

Interrupting normal metabolism of nucleic acids

Question 5

CA-125 is the tumour marker for?

Answer 5

Ocarian cancer

Question 6

What is the tumour marker for pancreatic cancer?

Answer 6

CA 19-9

Question 7

What is the tumour marker for breast cancer?

Answer 7

CA 15-3

Question 8

CEA is a tumour marker for?

Answer 8

Colorectal cancer

Question 9

Raised AFP and beta hCG indicates?

Answer 9

Non-seminomatous testicular cancer

Question 10

Raised AFP in an older woman indicates?

Answer 10

Liver cancer

Question 11

What cancer would you worry about in a patient with painless jaundice?

Answer 11

Pancreatic

Question 12

What is the breakthrough pain dosage?

Answer 12

1/6th of the daily dosage

Question 13

How would you treat metastatic bone pain?

Answer 13

Analgesia, bisphosphonates and radiotherapy

Question 14

How should opioid dosage be increased?

Answer 14

By 30-50%

Question 15

Which type of cancer has the strongest association with smoking?

Answer 15

Squamous cell lung carcinoma

Question 16

Oral morphine to subcut diamorphine conversion:

Answer 16

Divide by 3

Question 17

Oral morphine to subcut morphine conversion:

Answer 17

Divide by 2

Question 18

Oral morphine to oral oxycodone conversion:

Answer 18

Divide by 1.5-2

Question 19

Oral codeine or tramadol to oral morphine conversion rate:

Answer 19

Divide by 10

Question 20

What would you put in the syringe driver for respiratory secretions?

Answer 20

Hyoscine hydrobromide

Question 21

What would you put in the syringe driver for bowel colic?

Answer 21

Hyoscine butylbromide

Question 22

What would you put in the syringe driver for nausea and vomitinG?

Answer 22

Cyclizine

Question 23

What would you put in the syringe driver for agitation?

Answer 23

Midazolam, haloperifol

Question 24

What would you put in the syringe driver for pain?

Answer 24

Diamorphine

Question 25

What is the first line treatment for chemotherapy induced nausea?

Answer 25

Metoclopramide

Question 26

What is the 2nd line treatment for chemotherapy induced nausea?

Answer 26

Ondansetron and dexamethasone

Question 27

What type of drug is ondansetron?

Answer 27

5HT3 antagonist

Question 28

What kind of lung cancer do non smokers get?

Answer 28

Adenocarcinoma

Question 29

What would you prescribe for headaches and nausea caused by raiced ICP due to mets?

Answer 29

Dexamethasone

Question 30

What's a tumour marker for medullary thyroid cancer?

Answer 30

Calcitonin

Question 31

What type of cancer is thyroglobulin a tumour marker for?

Answer 31

Follicular or papillary thyroid cancer

Question 32

Which chemotherapy drugs cause peripheral neuropathy?

Answer 32

Vincristine, cisplatin

Question 33

Which chemo drugs cause cardiomyopathy?

Answer 33

Doxorubacin

Question 34

Which drug may cause lung fibrosis?

Answer 34

Bleomycin