Oncogenes-Tumor suppressor genes

Question 1

<p>abl</p>

Answer 1

<p>Oncogene - Tyrosine Kinase - CML</p>

Question 2

<p>C-MYC</p>

Answer 2

<p>Oncogene - Transcription factor - Burkitt's lymphoma</p>

Question 3

<p class=”large” style=”text-align:center”;>bcl-2</p>

Answer 3

<p class=”large” style=”text-align:center”;>Oncogene - Anti-apoptotic molecule - Follicular and undifferentiated lymphomas (inhibits apoptosis)</p>

Question 4

<p>HER2/neu (c-erbB2)</p>

Answer 4

<p>Oncogene - Tyrosine Kinase - breast, ovarian, and gastric carcinomas</p>

Question 5

<p>K-ras</p>

Answer 5

<p>Oncogene - GTPase - Colon carcinoma</p>

Question 6

<p>L-MYC</p>

Answer 6

<p>Oncogene - Transcription factor - Lung tumor</p>

Question 7

<p class=”large” style=”text-align:center”;>N-MYC</p>

Answer 7

<p class=”large” style=”text-align:center”;>Oncogene - Transcription factor - Neuroblastoma</p>

Question 8

<p>ret</p>

Answer 8

<p>Oncogene - Tyrosine kinase - MEN 2A/MEN 2B</p>

Question 9

<p>c-kit</p>

Answer 9

<p>Oncogene - Cytokine receptor - Gastrointestinal stromal tumor (GIST), which also has CD117</p>

Question 10

<p>Rb</p>

Answer 10

<p>Tumor suppressor gene - blocks G1-S phase vis E2F transcription factor - Retinoblastoma, osteosarcoma</p>

Question 11

<p>p53</p>

Answer 11

<p>Tumor suppressor gene - blocks G1-S phase - Most human cancers,Li-fraumeni syndrome</p>

Question 12

<p>BRCA1</p>

Answer 12

<p>Tumor suppressor gene - DNA repair protein - Breast and ovarian cancer</p>

Question 13

<p class=”large” style=”text-align:center”;>BRCA2</p>

Answer 13

<p class=”large” style=”text-align:center”;>Tumor suppressor gene - DNA repair protein - Breast and ovarian cancer</p>

Question 14

<p>p16</p>

Answer 14

<p>Tumor suppressor gene - Melanoma</p>

Question 15

<p class=”large” style=”text-align:center”;>BRAF</p>

Answer 15

<p class=”large” style=”text-align:center”;>Tumor suppressor gene - Melanoma</p>

Question 16

<p>APC</p>

Answer 16

<p>Tumor suppressor gene - Colorectal (associated with FAP)</p>

Question 17

<p>WT1</p>

Answer 17

<p>Tumor suppressor gene - Wilms' Tumor (nephroblastoma)</p>

Question 18

<p class=”large” style=”text-align:center”;>NF1</p>

Answer 18

<p class=”large” style=”text-align:center”;>Tumor suppressor gene - Neurofibromatosis Type 1</p>

Question 19

<p>NF2</p>

Answer 19

<p>Tumor suppressor gene - Neurofibromatosis Type 2</p>

Question 20

<p>DPC4</p>

Answer 20

<p>Tumor suppressor gene - Pancreatic cancer (Depleted in Pancreatic Cancer)</p>

Question 21

<p>DCC</p>

Answer 21

<p>Tumor suppressor gene - Colon cancer (Depleted in Colon Cancer)</p>