Tumor Markers

Question 1

<p>PSA</p>

Answer 1

<p>Used to follow prostate CA, but can also be inc in BPH and prostatitis</p>

Question 2

<p>CEA</p>

Answer 2

<p>CarcinoEmbryonic Antigen; A/w colorectal and pancreatic CA</p>

Question 3

<p>AFP</p>

Answer 3

alpha-fetoprotein; HCC, Yolk Sac (endodermal sinus) tumor of ovary or testes

Question 4

<p>beta-hCG</p>

Answer 4

<p>Hytidaform mole, Choriocarcinomas, Gestational trophoblastic disease</p>

Question 5

<p>CA-125</p>

Answer 5

<p>Ovarian CA</p>

Question 6

<p>S-100</p>

Answer 6

<p>Melanoma, neural tumors, schwannomas</p>

Question 7

<p>Alkaline phosphatase</p>

Answer 7

<p>Metastases to bone, liver; Paget's dx of bone</p>

Question 8

<p>Bombesin</p>

Answer 8

<p>Neuroblastoma, lung ca, gastric ca</p>

Question 9

<p>TRAP</p>

Answer 9

<p>Tartrate-Resistant Acid Phosphatase; Hairy cell leukemia (B-cell neoplasm); "TRAP the HAIRY animal"</p>

Question 10

<p>CA-19-9</p>

Answer 10

<p>Pancreatic adenocarcinoma</p>

Question 11

<p>Calcitonin</p>

Answer 11

<p>Medullary thyroid ca</p>

Question 12

<p>Chromogranin</p>

Answer 12

<p>Neuroendocrine cells; Seen in small cell carcinoma of the lung and in carcinoid tumors</p>

Question 13

Metastasis to Liver

Answer 13

Colon, Stomach, Pancreas, Breast, Lung: “Cancer Sometimes Penetrates Benign Liver”

Question 14

Metastasis to Brain

Answer 14

Lung, Breast, Skin (melanoma), Kidney (RCC), GI (colorectal): Lots of Bad Stuff Kills Glia

Question 15

Metastasis to Bone

Answer 15

Prostate, RCC, Thyroid/Testes, Lung, Lymphoma, Breast: “Permanently Relocated Tumors Like Long Bones”

Question 16

Metastasis from lungs

Answer 16

Pathoma pointed out lung loves going to adrenal gland