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Immuno Flashcards

1
Q

HLA A3

A

Hemochromatosis

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2
Q

HLA B27

A

PAIR - Psoriasis, Ankylosing spondylitis, Inflammatory bowel disease, Reiter’s syndrome

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3
Q

HLA DQ2.DQ8

A

Celiac disease

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4
Q

HLA DR2

A

MS, hay fever, SLE, Goodpasture’s

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5
Q

HLA DR3

A

DM Type I, Graves’ disease

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6
Q

HLA DR4

A

DM Type I, RA

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7
Q

HLA DR5

A

Pernicious anemia -> B12 deficiency, Hashimoto’s Thyroiditis

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8
Q

Upper limb/lateral breast

A

axillary nodes

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9
Q

Stomach

A

Celiac nodes

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10
Q

Dudoenum/Jejunum

A

SMA nodes

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11
Q

Sigmoid colon

A

Colic -> IMA nodes

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12
Q

Rectum (lower) and anal canal (above pectinate line)

A

Internal iliac nodes

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13
Q

Anal canal (below pectinate line)

A

Superficial inguinal nodes

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14
Q

Testes/ovaries

A

Paraortic nodes

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15
Q

Scrotum

A

Superficial inguinal nodes

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16
Q

Thigh (superficial)

A

Superficial inguinal nodes

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17
Q

Lateral side of dorsum of foot

A

Popliteal nodes

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18
Q

C3b

A

opsonization

19
Q

C3a, C5a

A

Anaphylaxis

20
Q

C5a

A

neutrophil chemotaxis

21
Q

C5b-C9

A

cytolysis by MAC

22
Q

CD16, CD56

23
Q

CD25, CD3, CD4

A

Regulatory T cells

24
Q

Severe, recurrent pyogenic sinus and respiratory tract infections (S. pneumo, H. influenzae), Inc susceptibility to Type III hypersensitivity (esp. gloerulonephritis)

A

C3 deficiency

25
Q

Defect in BTK (tyrosine kinase) -> no B cell maturation; recurrent bacterial infections after 6 months; dec immunoglobulins of all classes

A

X-linked (Bruton’s) agammaglobulinemia

26
Q

Most common primary immunodeficiency; False-positve beta-hCG due to presence of heterophile Ab; sinopulmonary infections

A

Selective IgA deficiency

27
Q

Tetany, recurrent vital/fungal infection, congenital and heart and great vessel disease

A

Thymic aplasia (DiGeorge)

28
Q

Dec TH1 response; disseminated mycobacterial infections, dec IFN-gamma

A

IL-12 deficiency

29
Q

Eczema, reccurrent staph abscesses, coarse facial features

A

Hyper-IgE (Job’s) - inability of neutrophils to respond to chemotactic stimuli due to TH1 cells failing to produce IFN-gamma

30
Q

Defective IL-2 receptor; adenosine deaminase deficiency; absence of thypic shadow

31
Q

Failure to thrive, chronic diarrhea, recurrent infections (candida, RSV, VZV, HSV, measles, flu, parainfluenza)

32
Q

Defects in ATM gene which codes for DNA repair enzymes; cerebellar defects, spider angiomas; IgA deficiency; Inc AFP

A

Ataxia-Telengectasia

33
Q

Usually defective CD40L on T cells -> inability to class switch; Inc IgM, dec IgG/IgA/IgE; X-linked

A

Hyper-IgM syndrome

34
Q

WAS gene; T cells unable to reorganize actin cytoskeleton; Inc IgA, dec IgM; X-linked

A

Wiskott-Aldrich syndrome

35
Q

Thrombocytopenic purpura, Infections, Ezema

A

Wiskott-Aldrich syndrome

36
Q

Defect in LFA-1 integrin (CD18); recurrent bacterial infections w/ absent pus formationl delayed separation of umbilical cord; neutrophilia

A

Leukocyte adhesion deficiency (type 1) - neutrophils fail to respond to chemotactic stimuli

37
Q

Defect in lysosomal trafficking regulator gene (LYST); microtubule dysfunction; giant granules in neutrophihls

A

Chediak-Higashi syndrome

38
Q

Partial albinism, neurological defects, recurrent pyogenic infections

A

Chediak-Higashi syndrome

39
Q

Lack of NADPH oxidase -> dec reactive oxygen species; inc susceptibility to catalase-positive organisms (S. aureus, E. Coli, Aspergillus, Pseudomonas, Nocardia, Serratia); Abnormal dihydrorhodamine (DHR) flow cytometry test; Negative nitroblue tetrazolium dye test; X-linked

A

Chronic granulomatous disease

40
Q

CD 14, CD 40, MHC II, B7

A

Macrophages

41
Q

CD19, CD20, CD21, MHC II, B7

42
Q

CD4, CD40L

A

Helper T cells

43
Q

CD8

A

Cytotoxic T cells

Step 1 (19 decks)

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