Autoantibodies

Question 1

<p>Antinuclear antibodies (ANA)</p>

Answer 1

<p>SLE, non-specific</p>

Question 2

<p>Anti-dsDNA, anti-Smith</p>

Answer 2

<p>SLE, anti-dsDNA more specific for SLE renal dx</p>

Question 3

<p class=”large” style=”text-align:center”;>Anti-histone</p>

Answer 3

<p class=”large” style=”text-align:center”;>Drug-induced lupus, may also be systemic</p>

Question 4

<p>Rheumatoid factor, anti-CCP</p>

Answer 4

<p>Rheumatoid arthritis (RF is an anti-IgG Ab, anti-CCP is more specific)</p>

Question 5

<p class=”large” style=”text-align:center”;>Anti-centromere</p>

Answer 5

<p class=”large” style=”text-align:center”;>Scleroderma (CREST syndrome)</p>

Question 6

<p>Anti-Scl-70 (anti-DNA topoisomerase I</p>

Answer 6

<p>Scleroderma (diffuse)</p>

Question 7

<p class=”large” style=”text-align:center”;>Anti-mitochondrial</p>

Answer 7

<p class=”large” style=”text-align:center”;>Primary biliary cirrhosis, if negative think autoimmune hepatitis</p>

Question 8

<p>IgA antiendomysial</p>

Answer 8

<p>Celiac Dx</p>

Question 9

<p class=”large” style=”text-align:center”;>IgA anti-tissue transglutaminase</p>

Answer 9

<p class=”large” style=”text-align:center”;>Celiac Dx</p>

Question 10

<p>Anti-basement membrane</p>

Answer 10

<p>Goodpasture's sxr</p>

Question 11

<p class=”large” style=”text-align:center”;>Anti-desmoglein</p>

Answer 11

<p class=”large” style=”text-align:center”;>Pemphigus vulgaris</p>

Question 12

<p>Antimicrosomal, anti-thyroglobulin</p>

Answer 12

<p>Hashimoto's thyroiditis</p>

Question 13

<p>Anti Jo-1, anti-SRP, anti-Mi-2</p>

Answer 13

<p>Polymyositis, dermatomyositis</p>

Question 14

<p class=”large” style=”text-align:center”;>Anti-SSA (anti-Ro)</p>

Answer 14

<p class=”large” style=”text-align:center”;>Sjorgren’s sxr, or SLE</p>

Question 15

<p>Anti-SSB (anti-La)</p>

Answer 15

<p>Sjorgren's sxr</p>

Question 16

<p class=”large” style=”text-align:center”;>Anti-U1 RNP (ribonubleoprotein)</p>

Answer 16

<p class=”large” style=”text-align:center”;>Mixed connective tissue dx</p>

Question 17

<p>Anti-smooth muscle</p>

Answer 17

<p>Autoimmune hepatitis</p>

Question 18

<p>Anti-glutamate decarboxylase (aka anti-glutamic acid decarboxylase (anti-GAD))</p>

Answer 18

<p>Type I DM</p>

Question 19

<p class=”large” style=”text-align:center”;>c-ANCA (PR3-ANCA)</p>

Answer 19

<p class=”large” style=”text-align:center”;>Granulomatosis with polyangiitis (Wegener’s)</p>

Question 20

<p>p-ANCA</p>

Answer 20

<p>Microscopic polyangiitis, Churg-Strauss sxr</p>

Question 21

<p class=”large” style=”text-align:center”;>Anti-TSH receptor</p>

Answer 21

<p class=”large” style=”text-align:center”;>Grave’s dx (actually stimulates receptor)</p>

Question 22

<p>Anti-Ach receptor</p>

Answer 22

<p>Myasthenia Gravis</p>

Question 23

<p>Anti-liver-kidney Ab</p>

Answer 23

<p>Autoimmune hepatitis</p>

Question 24

<p>MPO-ANCA</p>

Answer 24

<p>Pauci-immune crescenteric glomerulonephritis</p>