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Step 1 > Drug reactions > Flashcards

Drug reactions Flashcards

1
Q

Coronary vasospasm

A

Cocaine, sumatriptan, ergot alkaloids

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2
Q

Cutaneous flushing

A

Vancomycin, Adenosine, Niacin, CCBs (“VANC”)

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3
Q

Dilated cardiomyopathy

A

Doxorubicin, Daunorubicin

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4
Q

Torsades de pointes

A

Class III (sotalol) and class IA (quinidine) anti-arrhythmics, QPIDDS - Quinidine, Procrainimide, Ibutilide, Dofetilide, Disopyramide, Sotalol

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5
Q

Agranulocytosis

A

Clozapine, Carbamazepine, Colchicine, Propylthiouracil (PTU), Methimazole, Dapsone, “Agranulocytosis Could Certainly Cause Pretty Major Damage,” Tx by stopping drug and giving G-CSF

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6
Q

Aplastic anemia

A

Chloramphenicol, benzene, NSAIDs, Propylthiouracil (PTU), Methimazole

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7
Q

Direct Coombs-positive hemolytic anemia

A

Methyldopa, PCN

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8
Q

Gray baby syndrome

A

Chloramphenicol

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9
Q

Hemolysis in G6PD-deficient patients

A

Isoniazid (INH), Sulfonamides, Primaquine, ASA, Ibuprofen, Nitrofurantoin; “Hemolysis IS PAIN”

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10
Q

MegaloBLASTic anemia

A

Phenytoin, MTX, Sulfa drugs; “Having a BLAST with PMS”

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11
Q

Thrombotic complications

A

OCPs (i.e. estrogens)

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12
Q

Cough

A

ACE-inhibitors

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13
Q

Pulmonary fibrosis

A

BLeomycin, Amiodarone, Busulfan; “It’s hard to BLAB when you have pulmonary fibrosis”

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14
Q

Acute cholestatic hepatitis, jaundice

A

Erythromycin

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15
Q

Focal to massive hepatic necrosis

A

Halothane, Aanita phalloides (found in poisonous mushrooms - inhibit RNA polymerase II, which dec mRNA synthesis), Valproic acid, Acetaminophen; “Liver ‘HAVAc’”

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16
Q

Hepatitis

A

INH, Pyrazinamide

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17
Q

Pseudomembranous colitis

A

Clindamycin, ampicillin

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18
Q

Adrenocortical insufficiency

A

Glucocorticoid withdrawal (HPA suppression)

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19
Q

Gynecomastia

A

Spironolactone, Digitalis, Cimetidine, chronic Alcohol use, estrogens, Ketoconazole, marajauna, heroin; “Some Drugs Create Awesome Knockers”

20
Q

Hot flashes

A

Tamoxifen, clomiphene

21
Q

Hyperglycemia

A

Niacin, tacrolimus, protease inhibitors, HCTZ, corticosteroids

22
Q

Hypothyroidism

A

Lithium, amiodarone, sulfonamides

23
Q

Fat redistribution

A

Glucocorticoids, protease inhibitors

24
Q

Gingival hyperplasia

A

Phenytoin, verapamil, cyclosporine

25
Q

Gout

A

Furosemide, thiazides, niacin, cyclosporine, pyrazinamide

26
Q

Myopathies

A

Fibrates, Niacin, Colchicine, Hydroxychloroquine, Ifn-alpha, Penicillamine, Statins, Glucocorticoids; Fish N CHIPS Give you myopathies

27
Q

Osteoporosis

A

Corticosteroids, heparin

28
Q

Photosensitivity

A

Sulfonamides, Amiodarone, Tetracycline; “SAT for a photo”

29
Q

Rash (Stevens-Johnson syndrome)

A

PCN, Ethosuximide, Carbamazepine, Sulfa drugs, Lamotrigine, Allopurinol, Phenytoin, Phenobarbitol; “bad rash after a PEC SLAPP” (ECLPP are seizure drugs)

30
Q

SLE-like syndrome

A

Sulfonamides, Hydralazine, INH, Procainamide, Phenytoin; “SHIPP” linked to drugs that are metabolized via N-acetylation in liver (Phase 2)

31
Q

Teeth (kids)

A

Tetracyclines

32
Q

Tendonitis, tendon rupture, and cartilage damage

A

Fluoroquinalones

33
Q

Diabetes Insipidus

A

Lithium, demeclocycline

34
Q

Fanconi’s syndrome

A

Expired tetracycline

35
Q

Hemorrhagic cystitis

A

Cyclophosphamide, ifosfamide (prevent by co-admin with mesna)

36
Q

Interstitial nephritis

A

Methicillin, NSAIDs, furosemide

37
Q

SIADH

A

Carbamazepine, cyclophosphamide

38
Q

Cinchonism

A

Quinidine, quinine

39
Q

Parkinson-like syndromes

A

Anti-psychotics, reserpine, metoclopramide

40
Q

Seizures

A

INH, Buproprion, Impipenem/cilastatin, Tramadol, Enflurane, Metoclopramide; “with seizures, I BITE My tongue”

41
Q

Tardive dyskinesia

A

Anti-psychotics

42
Q

Anti-muscarinic

A

Atropine, TCAs, H1-blockers, neuroleptics

43
Q

Disulfuram-like reaction

A

Metronidazole, certain cephalosporins, procarbazine, 1st-gen sulfonylureas

44
Q

Nephrotoxicity/Ototoxicity

A

Aminoglycosides, Vancomycin, Loop diuretics, Cisplatin

45
Q

Abx to avoid in pregnancy

A

Countless SAFe Moms Take Really Good Care; Clarithromycin (embryotoxic), Sulfonamides (kernicterus), Aminoglycosides (ototoxicity), Flouroquinalones (cartilage damage), Metronidazole (mutagenesis), Tetracyclines; (discolored teeth/inhibition of bone growth), Ribavirin (teratogenic), Griseofulvin (teratogenic), Chloramphenicol (“gray baby” sxr)

46
Q

Serotonin syndrome

A

SSRIs, SNRIs, MAOIs, TCAs, Tramadol, Odansteron, Linezolid,Triptans

Step 1 (19 decks)

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