Class Labs/Findings

Question 1

“Apple core” lesion in abd xray

Answer 1

colorectal ca (usually left-sided)

Question 2

Azurophilic peroxidase-positive granular inclusions in granulocytes and myeloblasts

Answer 2

Auer rods (AML, especially M3 type)

Question 3

Bacitracin response

Answer 3

Sensitive: Strep pyogenes (group A); Resistant: strep agalactiae (group B)

Question 4

“Bamboo spine” on xray

Answer 4

Ankylosing spondylitis

Question 5

Basophilic nuclear remnants in RBCs

Answer 5

Howell-Jolly bodies (due to splenectomy or nonfunctional spleen)

Question 6

Basophilic stippling of RBCs

Answer 6

Lead poisioning or sideroblastic anemia

Question 7

Bloody tap on LP

Answer 7

Subarachnoid hemorrhage

Question 8

“Boot shaped” heart on xray

Answer 8

Tetralogy of Fallot, RVH

Question 9

Branching gram-positive rods with sulfur granules

Answer 9

Actinomyces israelii

Question 10

Bronhogenic apical lung tumor on imaging

Answer 10

Pancoast tumor (can compress SANS ganglion and cause Horner’s syndrome)

Question 11

“Brown” tumor of bone

Answer 11

Hyperparathyroidism or osteitis fibrosa cystica (deposited hemosiderin from hemorrhage gives brown color)

Question 12

Cardiomegaly w/ apical atrophy

Answer 12

Chagas’ disease (Trypanosoma cruzi)

Question 13

Cellular crescents in Bowman’s capsule

Answer 13

Rapidly progressive crescenteric glomerulonephritis

Question 14

“Chocolate cyst” of ovary

Answer 14

Endometriosis (frequently involves both ovaries)

Question 15

Circular grouping of dark tumor cells surrounding pale neurofibrils

Answer 15

Homer-Wright rosettes (neuroblastoma, medulloblastoma, retinoblastoma)

Question 16

Colonies of mucoid Pseudomonas in lungs

Answer 16

Cystic fibrosis (autosomal-recessive mutation in CFTR resulting in fat-soluble vitamin deficiency and mucous plugs)

Question 17

Dec AFP in amniotic fluid/maternal serum

Answer 17

Down syndrome or other chromosomal anatomy

Question 18

Degeneration of dorsal column nerves

Answer 18

Tabes dorsalis (3* syphilis), subacute combined degeneration (dorsal columns and lateral corticospinal tracts affected)

Question 19

Depigmentation of neurons in substantia nigra

Answer 19

Parkinson’s dx (basal ganglia dxr: rigidity, resting tremor, bradykinesia)

Question 20

Desquamated epithelium casts in sputum

Answer 20

Curschmann’s spirals (bronchial asthma; can result in whorled mucous plugs)

Question 21

Disarrayed granulosa cells in eosinophilic fluid

Answer 21

Call-Exner bodies (granulosa-theca cell tumor of the ovary)

Question 22

Dysplastic squamous cervical cells w/ nuclear enlargement and hyperchromasia

Answer 22

Koilocytes (HPV: predisposes to cervical CA)

Question 23

Enlarged cells w/ intranuclear inclusion bodies

Answer 23

“Owl’s eye” appearance of CMV

Question 24

Enlarged thyroid cells with ground-glass nuclei

Answer 24

“Orphan Annie’s eyes” nuclei (papillary carcinoma of the thyroid)

Question 25

Eosinophilic cytoplasmic inclusion in liver cel

Answer 25

Mallory bodies (alcoholic liver disease)

Question 26

Eosinophilic cytoplasmic inclusion in nerve cell

Answer 26

Lewy body (Parkinson’s dx)

Question 27

Eosinophilic globule in liver

Answer 27

Councilman body (toxic or viral hepatitis, often yellow fever)

Question 28

Eosinophilic inclusion bodies in cytoplasm of hippocampal nerve cells

Answer 28

Negri bodies of rabies (Lyssavirus)

Question 29

Extracellular amyloid deposition in gray matter of brain

Answer 29

Senile plaques (Alzheimer’s dx)

Question 30

Giant B cells with bilobed nuclei with prominent inclusions (“owl’s eye”)

Answer 30

Reed-Sternberg cells (Hodgkin’s disease)

Question 31

Glomerulus-like structure surrounding vessel in germ cells

Answer 31

Schiller-Duval bodies (yolk-sac tumor)

Question 32

“Hair on end” (Crew-cut) appearance on x-ray

Answer 32

Beta-thalassemia, sickle cell anemia (marrow expansion)

Question 33

hCG elevated

Answer 33

Choriocarcinoma, hytidaform mole (occur with and without embryo)