Obstetric Cholestasis

Question 1

pathophysiology?

Answer 1

thought to be a result of high oestrogen levels–> birth of baby resolves condition

Question 2

aetiology?

Answer 2

genetic component potentially- higher occurrence in south asian women

Question 3

presentation?

Answer 3

• itchiness
  
  • mainly palms of hands & soles of feet
• jaundice

later in pregnancy (3rd trimester)

Question 4

on investigation?

Answer 4

deranged LFTs and bile acids

Question 5

Mx?

Answer 5

• ursodeoxycholic acid
• emollients
  
  • help soothe skin
• antihistamines
  
  • can help sleeping
• vitamin K (if PT prolonged)
  
  • due to malabsorption

weekly LFTs to monitor & IOL at 37 weeks