Nutrition for Reproduction Flashcards

1
Q

What is the length of embryonic development in humans? Dogs? Cats? Chickens, Horses? Elephants?

A

Humans: 280 days
Dogs: 63 days
Cats: 62-72 days
Chickens: 21 days
Horses: 330-345 days
Elephants: 22 months

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2
Q

When do energy requirements increase in dogs? What BCS should you feed a bitch to? What RER should a whelping bitch receive?

A

• 15- 20% gain in BW prior to whelping
• 5% fetal mass developed by 40 days
• Therefore, energy requirements do not
increase until day 40
• begin to increase food intake @40d so at
whelping bitch receives 1.25 X MER
• Feed to BCS 5

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3
Q

How should you feed a pregnant dog?

A

Gravid uterus may impair gastric filling
• Feed several smaller meals
• Feed high energy food (4.0 kcal/g)
• Feed high protein food (7g protein/kg BW or about 25% crude protein dry matter)
• Requirements for fatty acids, calcium, phosphorous and certain amino acids increased after day 40
• Typically- feed an ‘all-life stages’ or puppy food

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4
Q

How do you feed the reproducing queen? Lactation? Pregnancy?

A

• Queens should be kept at an ideal BCS
• Excess body fat may result in decreased
conception rates and increased risk of dystocia
• Low BCS could risk fewer kittens, poor kitten body condition score, poor conception rate
• During pregnancy queens increase in bodyweight is almost linear
• Different from dogs
• Energy requirements increase and peaks at 6-7
weeks (1.6 RER at breeding- 2 RER at parturition)
• Lactation: All kittens should nurse within 6-8 hours of
birth
• Energy requirements for the queen peak 6-8 weeks
after parturition (2-6 RER)

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5
Q

What percentage of food consumption increase should you see for a queen in gestation? Pre-weaning ? reconstitution of reserves?

A

Gestation : 30-70% increase
Pre- weaning: 100-300% increase
Reconstitution of reserves: intake will decrease rapidly between week 7-11 back to maintenance.

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6
Q

What are the nutition requirements during lactation of both dogs and cats?

A
  • 5-10% increase in BW pre-breeding to post whelping
  • More not necessary due to capacity for increased food intake
  • Obesity at whelping may predispose to dystocia
  • Nutrient requirement is proportional to milk • Production energy costs may reach 4-8X RER (depending on # puppies)
  • At peak bitch’s milk production may reach 8% BW = to average dairy cow
  • Bitch milk is higher in fat and protein than cow milk
  • Free feed during lactation- high protein, high fat diet
  • Typically recommended using puppy diet ad lib or to maintain BCS
  • Don’t forget water!
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7
Q

What are the nutritional requirements of neonates?

A

• Milk contains all the energy and
other nutrients necessary for growth
during the first 3 weeks of life
• Low concentrations of some
minerals (Fe,Cu, Zn etc) are
compensated for by body stores
and the addition of solid food
during weaning

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8
Q

How is immunity transferred to offspring?

A
  • Transfer of immunity from mother to offspring:
  • transplacental immunity
  • colostral immunity
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9
Q

What are neonates susceptible to at birth? What are some examples?

A
  • At birth, the neonate presents an increased susceptibility to infectious agents due to functional immaturity of the immune system
  • For example:
  • Neutrophils have a small storage pool at birth, and this cell lineage is less responsive to chemoattractants
  • Monocytes/macrophages are functionally adequate but have limitations in chemotactic responsiveness
  • produce less IFN-α, IFN-γ, and IL-12
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10
Q

What maternal antibody is transferred across the placenta? What is the neonatal receptor that transports IgG?

A
  • Of the five antibody classes, only significant amounts of IgG are transferred across the placenta
  • transport of IgG is carried out by the neonatal Fc receptor (FcRn)
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11
Q

What is needed for maternal antibody transfer? When does it begin? What is the trend of fetal to maternal abs?

A
  • transport requires a healthy placenta
  • Begins at 17 weeks (humans) increases with gestation
  • By week 40 (humans): IgG(fetal)> igG (maternal)
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12
Q

What is colostrum? How do young animals receive and use colostrum?

A

• Colostrum is the antibody-rich fluid produced from the mother’s mammary glands during the first day or two after
birth
• Young animals can absorb antibodies intact for the first couple of days following birth
• Colostrum production is influenced by maternal hormones which support the development of the mammary gland
at late gestation

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13
Q

How is maternal immunity transferred via colostrum?

A

• Immunoglobulins represent the most important class of proteins in the colostrum
• In many species, IgG1 are the most important immunoglobulins present in colostrum
• The higher levels of IgG1 in colostrum than in serum corresponds to a selective transfer which becomes active in the weeks before parturition
• A class of Ig G1 receptors in the mammary epithelium having high affinity are present during the last 15 days of gestation
• The presence of these receptors decrease
immediately after the first suckling
• 2 days later, the concentration of IgG
decreases considerably
• Later, the milk proportion of IgA:igG increases

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14
Q

Why is the ingestion of maternal milk important in the first 24 hours after birth?

A
  • In the first 24 h after birth, the newborn must ingest immunoglobulin-rich colostrum which provides passively acquired immune protection throughout the neonatal period
  • Once the gastrointestinal tract matures, IgG can no longer transverse the intestines
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15
Q

What is failure of passive transfer?

A
  • Failure of passive transfer (FPT) is not a disease, but a condition that predisposes the neonate to the development of disease
  • In domestic large animals, the placenta prevents transmission of immunoglobulins from the dam to the fetus in utero
  • Neonates that do not nurse on colostrum in time, develop susceptibility to disease
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16
Q

What is the treatment of Failure of passive transfer?

A
  • Surrogate colostrum
  • Plasma may be used for infusion of antibodies
  • Prevention of pathogen exposure
17
Q

Why are newborn puppies highly dependent on their mothers? What percentage of IgG is obtained by placental transfer? How is the remainder obtained?

A

• Newborn puppies are highly dependent on their mothers
• Unable to walk
• Unable to hear/see
• unable to regulate body temperature
• Unable to spontaneously urinate and defecate
• Ineffective immune system
• Only 1-7% of the IgG obtained by passive transfer are by
placental transfer • The rest are through colostrum

18
Q

What level of IgG in a puppy is considered deficient? What puppies are more sensitive to deficiency? What is the issue with milk replacers?

A
  • Puppies w/ IgG below 230 mg/dl are deficient= increased 9X risk for mortality
  • Large breed puppies appear more sensitive
  • The proportion of IgA increases with time.
  • IgA have a role in mucosal immunity
  • Milk replacers can provide many nutritional needs; however, they do not provide immunity
19
Q

What is colostrum banking? What is the issues with that? How is it stored?

A
  • Donor colostrum is collected 24 hours after whelping
  • The IgG concentration decreases from 3830 mg/dl to 1730 mg/dl after 24 hrs
  • The colostrum is frozen until use
  • Freezing/thawing has minimal effect on antibody activity
20
Q

What is heterologous immunity?

A

Heterologous immunity- the induction of an immune response to an unrelated pathogen/antigen upon exposure to a different pathogen/antigen.
- would not protect against canine specific pathogens

21
Q

What is canine plasma transfusion? Can it be used for IgG transfer?

A
  • Use of IV transfusion in neonates is done in people
  • Oral and Subcutaneous administration has been used with variable success in terms of IgG transfer
  • However, there are other benefits on growth and health
22
Q

What are the benefits of canine plasma transfusion in neonates?

A
  • oral plasma supplementation (twice within the first 8 hr of life and since Day 2 of life, every 2 days until 56 days)
  • greater weight gain, increased intestinal microbiota diversity
23
Q

What is hyperimmune egg powder?

A

Hyperimmune egg powder
• Hens vaccinated against canine microbes
• The yolk is rich in canine antibodies
• May improve growth

24
Q

What is important to monitor in neonates post birth? What is the rate of mortality? when do deaths normally occur? What are concerns for neonates? When could these issues occur?

A

• Mortality varies between species and
breeds, but can reach 10-30%
• About 1/3 of deaths occur in the first
week, and ~2/3 in the two weeks after
• Important to diagnose problems early
Monitor
• Activity
• weight gain
• body temp
• hydration
• stool quality
• muscle tone

• Hypoglycemia, Hypothermia, Dehydration

• Time period- first week especially first 3
days (in toy breeds risk may be for
longer)

25
Q

What is the etiology of hypoglycemia, hypothermia, dehydration? What are the clinical signs? treatments?

A

Etiology:
• Decreased food intake
• High requirements, low reserves
• Low environmental temperature
• Disease (diarrhea)
Clinical signs:
• initially- vocalizing, active
• with time- sluggish, cool (below 94 F)
• poor skin turgor
• often rejected by bitch
Treatment:
• increase core temperature slowly to 94-98 F
• correct low BG
• correct dehydration (1 ml/30g BW)

26
Q

What are the energy requirements for orphaned puppies? How can you feed them? How often must they be fed? What else must you do to take care of them?

A

Age (weeks) -MER (kcal/kg/d)
0-1 : 140
1-2 : 150
2-3: 190
3-4 : 200
weaning: 130
• Treatment:
• Bottle/Dropper feeding
• Tube Feeding
• 5-8 fr catheter
• measure nose to last rib and mark tube • feed slowly (2 minutes) • 6-8 feedings a day best (4 may suffice) • massage perineal region with moist cotton ball
MER (kcal/kg/d) 140 150 190 200 130

27
Q

What is important to know about formulas?

A

• Use a reputable product/brand
• Even the best products are not equal to natural bitch/queen milk, so a foster is always
preferred

28
Q

What are some dangers of an unbalanced diet in neonates that cause cataracts?

A

Deficiencies: Vitamin A, Vitamin E, Riboflavin, Calcium, Tryptophane, Methionine, Arginine, Cystine
Excess: Glucose, lactose, galactose, xylose

29
Q

What is occurring in this image?

A

Immature cataract caused by canine milk replacer.

30
Q

When are puppies weaned? How should moms diet change? How should you wean puppies? Following the correct weaning procedure will prevent what in bitches?

A
  • 6 to 8 weeks of age
  • Decrease Mom’s food intake 50%

• Remove pups during the day for 1-3 days before removing them
completely

  • DON’T limit water intake
  • This procedure allows monitoring of pups for adequate food intake
  • Helps prevent mastitis in the bitch
31
Q

When does total food intake plateau in puppies? What are the rules of thumb for estimating energy intake during growth? When do puppies have a higher risk of weight gain?

A
  • Rules of thumb for estimating energy intake during growth:
  • 2 X MER for weaning to 1/2 adult BW
  • 1.5 X MER for 1/2 - 3/4 adult BW
  • 1.2-1.0 MER for 3/4 to 1.0 adult BW
  • Often total food intake plateaus between 4 and 5 months

• Once neutered, higher risk of weight gain

32
Q

What is associated with fast growth post weaning in puppies? How can you prevent it? What dogs are more at risk?

A

Fast growth is associated with increased risk of skeletal disease in large breeds

  • Maintain at BCS of 4/9
  • Especially in large breeds
  • Use growth curves to monitor puppies development and monitor for weight gain/ obesity
33
Q
A