Nutrient metabolism Flashcards
Disease associated with Mal-digestion
Chronic pancreatitis
CF
Pancreatic carcinoma
Inadequate absorptive surface
Intestinal resection
Gastro colic fistula
Jejuno-ileal bypass
Bile salt deficiency
Cirrhosis Cholestasis Bacterial overgrowth Impaired ileal reabsorption Bile salt binders
Lymphatic obstruction
Lymphoma
Whipple’s disease
Intestinal lymphangiectasia
Vascular disease
Constructive pericarditis
Right sided HF
mesenteric arterial or venous insufficiency
Mucosal disease
Infection Inflammatory diseases Radiation enteritis Eosinophilic enteritis Ulcerative jejunitis
Cytokines in diseases with inflammatory responses
TNF-alpha - insulin resistance, glycolysis
IL2 - glucose metabolism
IL4 - glucose and lipid metabolism
IL6 - lipolysis
What does critical acute illness cause
Increase in synthesis of growth hormone
Anti-insulin effects
Anti-anabolic effects
Clinical manifestations of growth hormone increase
Hperglycaemia, hyperlipidaemia, hypercatabolic state, muscle wasting