Biochem 3 - Carb metabolism

Question 1

Action of PFK1

Answer 1

Glucose to pyruvate - glycolysis
F-6-P -> F-1,6-BP
Not controlled directly by hormones

Question 2

Action of F-1,6-BPase

Answer 2

OAA to glucose - gluconeogenesis
F-1,6-BP -> F-6-P
Not controlled directly by hormones

Question 3

Action of PFK2

Answer 3

F-6-P -> F-2,6-BP (which activates PFK1)

Question 4

Action of F-2,6-BPase

Answer 4

Glycolysis
F-2,6-BP -> F-6-P
Affected by hormones

Question 5

Glycolysis (and PFK-1) activated by

Answer 5

AMP
F-6-P
F-2,6-BP
Glucose

Question 6

Glycolysis (and PFK1) inhibited by

Answer 6

ATP
Citrate
H+ (signals lots of lactate - therefore enough pyruvate, not enough oxygen)

Question 7

Active form of F-2,6-BPase

Answer 7

Phosphorylated form

Activating it requires ATP

Question 8

Active form of PFK2

Answer 8

Dephosphorylated form

Does not require ATP (phosphorylating PFK2 requires ATP)

Question 9

Hormonal control of gluconeogenesis

Answer 9

Activated by Glucagon and adrenaline
Activated by Glucagon, glucocorticoids, thyroid hormones
Inhibited by insulin