NSAIDs 2: Food producing and performance animals Flashcards
Name 4 indications for NSAIDs
- analgesic
- anti-inflammatory
- anti-pyretic
- anti-thrombotic
2 broad effects of corticosteroids
- genomic (block transcription of inflammatory mediators)
- non-genomic
Name drugs which must NEVER be used in food producing animals in UK?
- Phenybutazone
- chloramphenicol
- metronidazole
- benzyl-penicillin (crystapen)
- metoclopramide
- lidocaine
- gentamicin/ amikacin
Human side effects of phenylbutazone
- fatal blood dyscrasias
- liver problems
- no safe determined minimum residue limit
Which species are ‘food producing’
- cattle
- sheep
- pigs
- goats
- horses
- chickens
- fish
- pot-bellied pigs (even if pets)
- pygmy goat (even if pets)
- camelids are a grey area*
How do we use bute in horses?
make a note in section A of passport
Why can’t we use phenylbutazone in camelids?
- not legal under EU regulations in food producing animals
- oral powder not bioavailable in ruminants
- half life in llamas
Which species have no licensed NSAIDs?
- goats
- sheep
- camelids
- USE CASCADE
Outline the order of the cascade
- vet med authorised in UK in another spp or for a different condition in same spp
- med authorised in UK for human or vet med product not authorised in UK but in a member state (must be in a food producing animal) in accordance with import certificate from VMD
- medicine prescribed by vet prepared extemporaneously by vet, pharmacist or person holding manufacturer authorisation
What are the minimum withdrawals for drugs under cascade?
- 7 d (eggs, milk)
- 28d (meat and poultry)
- 500 degree days meat from fish
List NSAIDs that are licensed for food animals - 5
- MELOXICAM: cattle, pigs, horses
- FLUNIXIN: cattle, pigs, horses
- KETOPROFEN: cattle, pigs, horses
- CARPROFEN: cattle, horses
- TOLFENAMIC ACID: cattle, pigs
Outline flunixin meglumine in food animals:
- species
- use
- side effects
- used in sheep/goats with cattle dosage under cascade
- alpacas under cascade dose for horses
- USE:
- visceral and ophthalmic pain
- systemic inflammation (mastitis, metritis)
- pain relief after elective surgeries
- SIDE EFFECTS: decreased cortisol, increased feed intake, increased daily weight gain
Describe meloxicam in food animals
- spp
- action
- uses
- most common NSAID in food animals
- licensed: cattle, pigs, horses
- preferential COX-2 inhib
- prolonged half life (esp. cattle)
- pain relief after sx
- now licensed for ‘relief of post-op pain following dehorning calves’
- effective against: systemic inflammation, visceral and ophthlamic pain, lameness in cattle
Describe ketoprofen in food animals:
- action
- use
- spp
- non-selective COX inhib
- short half life (limits use, multiple dose = off label)
- some reduction of bovine lameness
- some short term effects in toxic mastitic
- licensed and useful for reducing udder oedema in cattle
- not as effective as analgesic in elective sz or after LDA sx vs. other NSAIDs
- cattle, pigs, horses
Describe carprofen in food animals
- non-selective COX inhib in large animals
- prolonged half life in cattle, esp young animals (
Describe tolfenamic acid in food animals
- use
- spp
- not commonly used
- use: BRDC and acute mastitis as anti-inflammatory
- spp: cattle, pigs
Which might affect your choice of NSAID in food animals? 5
- spp licensed
- cost
- drug familiarity
- milk and meat withdrawals
- ROA
3 main adverse effects of NSAIDs in food animals
- abomasal ulcer
- renal toxicity
- care with hepatic dz
Which NSAIDs are licensed in horses? 8
- meloxicam
- flunixin
- phenylbutazone
- suxibuzone
- vedaprofen
- firocoxib
- carprofen
- ketoprofen
What might affect your choice of NSAID in horses?
- familiarity / clinician preference
- cost
- COX 2 selective vs. non-selective
- ROA
- intended/ labelled use
Describe phenylybutazone in horses
- non-selective COX1/2
- no evidence of tissue specificity
- less analgesic effects than flunixin meglumine
Describe suxibuzone in horses:
- what
- compare with bute
- pro-drug of phenylbutazone
- given orally
- more palatable vs. bute
- more expensive vs. bute
Describe flunixin meglumine in horses:
- action
- use
- non-selective COX1/2
- no evidence of tissue specificity
- good analgesic and effective vs. systemic inflammation
Describe meloxicam in horses:
- action
- use (2)
- dose
- COX2 preferential
- licensed for use in colic, acute/chronic MSK disorders
- pharmacokinetics show 2x daily dosing would improve efficacy