Nsaids

Question 1

What are the clinical uses of NSAIDs 5

Answer 1

*Rheumatic diseases
*neurological
*renal colic
*fever
* pain syndrome

Question 2

What is the mechanism of action

Answer 2

*inhibition of C0X 1 and CO2 which leads to stopping of synthesis of prostaglandins(E2,D2), thrombanxe A2,and prostacyclin

Question 3

Classification of NSAIDs

Answer 3

• selective COX 1 inhibitors: Aspirin
  *Non selective COX inhibitors: Aspirin,ibuprofen,Naproxen,ketoprofen,indomethacin
  *preferential COX 2inhibitors (NImesulide)Meloxicam
  *Selective COX 2 inhibitors: celecoxib,Etoricoxib, parecoxib

Question 4

Pharmacokinetics of NSAIDs

Answer 4

*main route of administration is oral and also given intravenously when there is renal colic

Question 5

Gastrointestinal side effects of Nsaids

Answer 5

prostaglandins E2! Is responsible for mucus secretions,bicarbonate,mucosal blood flow( inhibition of PGE2 leads to
*peptic ulcers
*GiT bleeding

Question 6

Renal side effects of NSAIDs are

Answer 6

pGE2 and PGI2 are responsible for afferent arteriolar vasodilation (increase in GFr) and Na and water excretion) inhibition of PGE2 and PGI2 leads to
*Na and water retention
*Hypertension
*kidney injury

Question 7

Cardiovascular side effects of NSAIDs COX 1 and COX 2 inhibitors( aspirin)

Answer 7

PGI2 and thrombanxe A2 are responsible for vasodilation, inhibit platelet aggregation
Inhibition of COX2 and COX 1 will lead to
*stroke
*myocardial infarction

Question 8

Drug interactions of NSAIDs

Answer 8

*increases digoxin concentration in plasma
* it decreases effectiveness of anti hypertensives

Question 9

Algorithm of administration of NSAIDs

Answer 9

*Proton pump inhibitors are given together with NSAIDs to protect the git