Anti-anginal Drugs

Question 1

What is the operative principle of antianginal drugs and oxygen demand to the myocardium

Answer 1

• myocardial oxygen demand is dependent on preload,after load and heart rate mean while
• Antianginal drugs inhibits preload,afterload and heart rate which helps to increase oxygen delivery to the myocardium and increases the coronary function

Question 2

List the drugs under the class of nitrates

Answer 2

*nitroglycerin
*Isosorbide mononitrate
*Isosorbide Dinitrate

Question 3

5 Clinical uses of nitrates

Answer 3

• Spastic angina
  *Unstable angina
  *Myocardial ischemia
  *hypertensive crisis

Question 4

Route of administration for nitroglycerin

Answer 4

*sublingual
*spray under the tongue
*nitroglycerin for injections

Question 5

Which drug is long acting vasodilating for treating angina but not in nitrate’s group

Answer 5

Molsidomine

Question 6

Calcium channel blockers groups

Answer 6

Dihydropiridines(amlodipine, nefipidine)
Pheylalkaline derivatives ( verapamil)
Benzodiazepines derivatives (diltiazem)

Question 7

Clinical uses of calcium channel blockers

Answer 7

*antianginal
*antiarrythmias
*anti hypertensive

Question 8

Name at least 1 drug in the classification of nonhydropyridipine calcium channel

Answer 8

1st generation- Nifidipine
2nd generation-Nicardipine, felodipine
3rd generation-Amlodipine
4th generation-larcadipine

Question 9

Sides effects of calcium channel blockers

Answer 9

• hypotension
  *constipation
  *dizziness
  *Angioedema

Question 10

Indications of ivabradine

Answer 10

*stable Angina
*heart failure
*sinus tachycardia