Hormones And Antihormonal Receptors Flashcards
Hormones of the pituitary include mention 5
*growth hormone
*follicle stimulating hormone
*oxytocin
*prolactin
*Gonadotropins -follicle stimulating hormone
Other hormones of the body 4
-*insulin (pancreas)
*thyroid hormone
*adrenal cortex:glucocorticoids
*parathyroid
Physiological function of growth hormone
Growth hormone is responsible for the growth of bones and body parts including the growth of brain and eyes by inducing hyperplasia
Excess production of growth hormone leads to
Gigantism
Hypo production of growth hormone leads to
Dwarfism
Clinical uses of growth hormone
Dwarfism
Human recombinant growth hormone (somatotropin) is used for the treatment of children with short stature and renal failure in children and Turner’s syndrome
Growth hormone inhibitors
*somatostatin
Clinical uses of somatostatin
- it is used in treatment of esophageal varies in term of bleeding it constrict blood vessels and reduce blood flow to the GIT this useful again diarrhea dyspepsia
- acromegaly
Clinical uses of octreotide( growth hormone inhibitors
Acromegaly
Hiv and aids
Cancer
Diarrhea
What are the prolactin inhibitors
Bromocriptine:it is used for inhibit release of prolactin: excess prolactin causes galactorrhea,amenohea so Bromocriptine is used to treat these conditions
3 uses of Bromocriptine
Acromegaly
Hyperprolactiemia
Parkinson’s disease
Diabetes mellitus
What are gonadotropics
Gonadotropin contains two types of hormones
Follicle stimulating hormone:for stimulation of follicle development and in males spermagogenesis
LH: for the maturation of graffian follicle to corpus leuteum
Disturbance of gonadotropins leads to
*delayed puberty in girls and boys
Clinical uses of gonadotropins analogues
*amenorrhea and infertility
Drug (menotropins) ,Recombinant human follicle stimulating hormone
*aid invitro fertilization
List 3 Agonists of gonadotropins
Naferelin
Goserelin
Triptorelin
