Antiplatelets

Question 1

What is the definition of hemoestasis and it’s processes

Answer 1

Hemoestasis is the stoppage of blood loss from the arteries and it involves platelet activation,adhesion and formation of fibrin mesh

Question 2

What is thrombosis

Answer 2

Thrombosis is the abnormal formation of hemostasis plug in the wrong place

Question 3

List the group of drugs that prevent hemoestasis and thrombosis and it’s activity

Answer 3

*Antiplatelets
*Anticoagulants
*fibrinolytics

Question 4

List the group of drugs that enhance or promote the activity of hemoestasis or thrombosis

Answer 4

*Antifibrinolytics(tranexamic acid)
*Coagulation factors

Question 5

List the receptors of platelets

Answer 5

*Adenosine diphosphate inhibitors ( P2y12 inhibitors
*Thrombanxe A2 inhibitor
*GPIIB/llla inhibitor
*PAF inhibitors
*Agents that increase adenosine and CAMP in platelet

Question 6

List drugs at least 3 that block Adenosine diphosphate (p2y12 )receptor

Answer 6

*clopidogrel
*prasugrel
*Ticlopidine
Cangrelor

Question 7

Give 5 clinical uses of p2y12 receptor inhibitors (Ticlopidine and clopidogrel)

Answer 7

*In myocardial infarction prevention and reduction of mortality rate
* intermittent claudication(Ticlopidine)
*ischemic stroke with patients with unstable angina
*Diabetic microangiopathy
*Thrombosis of peripheral blood vessels

Question 8

Clopidogrel can be combined with aspirin to prevent what disease?

Answer 8

Acute myocardial infarction and ischemic stroke

Question 9

What is the drug for antagonism of platelet activating factor (PAF inhibitors )

Answer 9

*TANaKaN

Question 10

Glycoprotein IIb/ IIIa inhibitors list the drugs

Answer 10

ABICXiMAB
Tirofiban
Eptifibatide

Question 11

Side effects of abciximab (5)

Answer 11

• Thrombocytopenia
  *AV block
  *arterial hypotension
  *Anemia
  *Bleeding

Question 12

Thromboxane A2 synthesis inhibitors and mechanism of action

Answer 12

Aspirin(acetysalicyclic acid) it inhibits cox1 enzyme leading to inhibition of synthesis of thromboxane A2

Question 13

Clinical uses of aspirin

Answer 13

*myocardial infarction
*acute coronary syndrome
*ischemic stroke
*Atrial fibrillation
* Venous thrombosis

Question 14

Agents that increase content of adenosine and cyclic CAMp in platelets and mechanism of action

Answer 14

Dipyridamol: by the increase of CAMp it leads to decrease release of calcium and that inhibits platelets aggregation