Antihypertensive Drugs

Question 1

Give 3 alpha adrenoceptor blocking agents

Answer 1

*Prazosin
*Doxazosin
*Tetrazosin

Question 2

Mention the 2 central acting adrenergic drugs

Answer 2

*clonidine
*Methyl dopa

Question 3

Describe mechanism of action of clonidine

Answer 3

*clonidine binds to alpha(a2) in the CNS and inhibits sympathetic outflow thus reducing peripheral resistance and that reduces blood pressure

Question 4

Mechanism of methyl dopa

Answer 4

Methyl dopa is a2 agonist that gets converted to methylepinephrine to diminish sympathetic outflow

Question 5

List the beta receptors locations and action

Answer 5

*B1: heart !! Increase heart rate, automaticity, force
*B2 : smooth muscle !! Relaxation
*B3: adipose tissue

Question 6

List 5 cardioselective beta blockers

Answer 6

*propanalol
*Bisoprolol
*Atenolol
*Metoprolol

Question 7

What is the. Mechanism of vasodilators

Answer 7

Dilatation of peripheral blood vessels which aids to reduce the peripheral resistance and blood pressure

Question 8

Mention a drug that activates potassium channels and opens it leading to hyperpolarisation

Answer 8

Minoxidil

Question 9

Side effects of minoxidil

Answer 9

*Hirsurtism: it promotes growth of hair it is used to treat baldness
*it causes retention of salt and water thus it is given with diuretics

Question 10

Mention the vasodilators that only act on arteries and arterioles

Answer 10

Hydralazine
Nitroprusside: it is used in hypertensive emergencies in Intensive care unit

Question 11

Endothelia receptor blocker is

Answer 11

Bosentan