non infectious inflammatory disease (pulm)

Question 1

multisystem granulomatous inflammatory disease of unk etiology

Answer 1

sarcoidosis

Question 2

which grps have highest risk for sarcoidosis?

Answer 2

Af Am, North Europeans, exposure to insecticides, agri, microbial bioaerosols

Question 3

what is lofgrens syndrome (3)

Answer 3

assc’d wtih sarcoidosis

1. erythema nodosum
2. polyarthralgia
3. bilateral hilar lympadenopathy

Question 4

what labs can be abnormal in sarcoidosis?

Answer 4

1. Ca level
2. liver enzymes
3. creatinine

Question 5

lupus pernio

Answer 5

sarcoidosis

Question 6

indications to start steroids in a sarcoidosis patient (3)

Answer 6

1. lupus pernio
2. heart block
3. uveitis

Question 7

PFT of sarcoidosis?

Answer 7

decr TLC, VC, RV

decr DLCO

Question 8

how to confirm suspicious of sarcoidosis?

Answer 8

bronchoscopy

Question 9

if there is evidence of systemic disease, how to tx sarcoidosis?

Answer 9

oral corticosteroids

Question 10

50% of patients present with ILD, more common in mean, non productive cough, dyspnea on exertion, inspiratory fine crackles + pleural rub

Answer 10

RA lung disease

Question 11

what to use to tx RA lung disease?

Answer 11

1. methotrexate
2. etanercept
3. inflixamab

Question 12

what is the most common cause of morbidity & mortality in scleroderma?

Answer 12

progressive systemic scleroderma lung disease

Question 13

2 forms of sclerodermal lung disease

Answer 13

1. interstitial lung disease

2. limited form (CREST syndrome) pulm HTN

Question 14

in limited form sclerodermal pulmonary HTN, what happens to DLCO?

Answer 14

decreased

Question 15

what is the most common presentation of SLE pulm involvement?

Answer 15

serositis

Question 16

effect of sjogrens syndrome on pulm fxn?

Answer 16

1. airway compromise

2. bronciectasis, bronchiolitis

Question 17

necrotizing granulomatous vasculitis of small and medium vessels; involves upper & lower RT, renal; presents w/ cough, hemoptysis, sinus sx?

Answer 17

wegener’s granulomatosis

Question 18

how to test for wegener’s granulomatosis?

Answer 18

cANCA testing

Question 19

pulmonary-renal syndrome, alveolar hemorrhage, hemopytsis possible

Answer 19

goodpasture’s syndrome

Question 20

how to dx goodpasture’s syndrome?

Answer 20

anti-glomerular base membrane Ab

Question 21

how to gather samples to dx goodpasture’s syndrome?

Answer 21

bronchoscopy

Question 22

tria of asthma + hypereosinophilia + necrotising vasculitis

Answer 22

churg-strauss syndrome

Question 23

what are the phases of churg-strauss syndrome?

Answer 23

1. prodromal

2, eosinophilic phase

Question 24

what happens during prodromal phase of churg-strauss?

Answer 24

rhinitis, sinusitis, asthma

Question 25

what happens during eosinophilic phase of churg-strauss?

Answer 25

peripheral eosinophilia, eosinophilic pneumonia, vasculitis

Question 26

how to test for churg strauss

Answer 26

CBC - need to define eosinophilia, elevated IgE, positive pANCE