arterial blood gases Flashcards
which form of Hb is low affinity?
T form
which form of Hb is high affinity?
R form
what reduces oxygen affinity?
lower pH, 2,3-BPG binding, higher conc CO2
reduced oxygen affinity stabilizes the T form or the R form?
increases/strengthens contact b/w subunits–>stabilizes T form
diminished contacts b/w subunits stabilizes which form of Hb?
R form
what diminishes contacts b/w subunits
increased oxygen affinity
higher pH, no 2,3 BPG binding, lower concentration of CO2 results in incr or decr oxygen affinity?
increased
what are the 3 forms that CO2 is moved in?
- dissolved in blood
- attached to Hb as N terminal carbamates
- bicarbonate ion
what does formation of carbamates and HCO3 generate?
H+
what form is CO2 predominantly found in?
bicarb ion
what is the haldane effect?
CO2 concentration of blood varies as a fxn of blood oxygenation (less total CO2 in oxygenated blood)
which is a stronger base? deoxyHb or oxygreanted Hb?
deoxyHb
proton binding ______O2 affinity, and facilitates oxygen_______
decreases, unloading
if you’re hypoventilating, what happens to the partial pressure of CO2?
incr
if you’re hyperventilating, what happens to the partial pressure of CO2?
decr
