arterial blood gases Flashcards
which form of Hb is low affinity?
T form
which form of Hb is high affinity?
R form
what reduces oxygen affinity?
lower pH, 2,3-BPG binding, higher conc CO2
reduced oxygen affinity stabilizes the T form or the R form?
increases/strengthens contact b/w subunits–>stabilizes T form
diminished contacts b/w subunits stabilizes which form of Hb?
R form
what diminishes contacts b/w subunits
increased oxygen affinity
higher pH, no 2,3 BPG binding, lower concentration of CO2 results in incr or decr oxygen affinity?
increased
what are the 3 forms that CO2 is moved in?
- dissolved in blood
- attached to Hb as N terminal carbamates
- bicarbonate ion
what does formation of carbamates and HCO3 generate?
H+
what form is CO2 predominantly found in?
bicarb ion
what is the haldane effect?
CO2 concentration of blood varies as a fxn of blood oxygenation (less total CO2 in oxygenated blood)
which is a stronger base? deoxyHb or oxygreanted Hb?
deoxyHb
proton binding ______O2 affinity, and facilitates oxygen_______
decreases, unloading
if you’re hypoventilating, what happens to the partial pressure of CO2?
incr
if you’re hyperventilating, what happens to the partial pressure of CO2?
decr
respiratory imbalances result from changes _________
PCO2
metabolic imbalances result from changes in_____
concentration of bicarb
hypoventilation results in PCO2 _____40 torr
above
hyperventilation results in PCO2 _____40 torr
under
what is respiratory compensation?
when the lungs hypo or hyperventilate to regulate PCO2; rapid response
what is renal compensation?
when the kidneys regulate bicarb concentration and regulate H+ excretion ; slow response
how does the body compensate for metabolic acidosis?
increased ventilation
how does the body compensate for respiratory acidosis?
kidneys incr plasma HCO3 concentration
how does the body compensate for respiratory alkalosis
kidneys excrete HCO3
how does body compensate for metabolic alkalosis?
hypoventilation
