lung pathology 4

Question 1

most common cause of malignant lesions in lung?

Answer 1

metastasis

Question 2

most common cause of benign lesions in lung?

Answer 2

granuloma

Question 3

most common metastasis sites?

Answer 3

breast, stomach, pancreas, colon

Question 4

peripheral, asymptomatic, slowly growing coin lesion (>1.5 cm w/o pulm disease)

Answer 4

pulm hamartoma

Question 5

most common presentations of lung cancer

Answer 5

cough, weight loss, trouble breathing

Question 6

serous fluid, usu caused by cardiac failure

Answer 6

hydrothorax

Question 7

blood in pleural space, usu ruptured aneurysm or vascular trauma or cancer

Answer 7

hemothorax

Question 8

lymphatic obstruction, thoracic duct injury

Answer 8

chylothorax

Question 9

hypercalcemia happens more commonly in sqaumous cell carcinoma or small cell carcinoma?

Answer 9

squamous cell carcinoma

Question 10

adenocarcinoma assc’d with what sort of mutations?

Answer 10

KRAS and EGFR

Question 11

most common lung cance rin women, younger patients, non-smokers

Answer 11

adenocarcinoma

Question 12

which cancer: precursor lesion is atypical adenomatous lesion

Answer 12

bronchioalveolar carcinoma

Question 13

origin of bronchioloalveolar carcinoma?

Answer 13

bronchioloalveolar stem cells (BASCs)

Question 14

which lung cancer grows rapidly, metastasizes more slowly, produces keratin

Answer 14

squamous cell carcinoma

Question 15

intercellular bridges, keratin pearls

Answer 15

squamous cell carcinoma

Question 16

what is the most malignant, aggressive type of lung cancer?

Answer 16

small cell carcinoma

Question 17

tx of choice for SCC?

Answer 17

chemo

Question 18

which type is known to have a high N/C ratio?

Answer 18

small cell carcinoma

Question 19

______is a dx of exclusion

Answer 19

large cell carcinoma

Question 20

undifferentiated carcinoma with early metastasis and poor prognosis

Answer 20

large cell carcinoma

Question 21

what type of lung cancer has the best 5 yr survival prognosis?

Answer 21

bronchioalveolar carcinoma

Question 22

common causes of death in those with lung cancer (5)

Answer 22

1. pneumona
2. lung abscess
3. bleeding
4. esophago-pleural fistula
5. effects of metastases on other organs

Question 23

localized non invasive soft tissue tumor, attached to pleural surface by pedicle

Answer 23

solitary fibrous tumor

Question 24

3 patterns of mesothelioma

Answer 24

1. epitheliod
2. sarcomatoid
3. combo