lung pathology 4 Flashcards
most common cause of malignant lesions in lung?
metastasis
most common cause of benign lesions in lung?
granuloma
most common metastasis sites?
breast, stomach, pancreas, colon
peripheral, asymptomatic, slowly growing coin lesion (>1.5 cm w/o pulm disease)
pulm hamartoma
most common presentations of lung cancer
cough, weight loss, trouble breathing
serous fluid, usu caused by cardiac failure
hydrothorax
blood in pleural space, usu ruptured aneurysm or vascular trauma or cancer
hemothorax
lymphatic obstruction, thoracic duct injury
chylothorax
hypercalcemia happens more commonly in sqaumous cell carcinoma or small cell carcinoma?
squamous cell carcinoma
adenocarcinoma assc’d with what sort of mutations?
KRAS and EGFR
most common lung cance rin women, younger patients, non-smokers
adenocarcinoma
which cancer: precursor lesion is atypical adenomatous lesion
bronchioalveolar carcinoma
origin of bronchioloalveolar carcinoma?
bronchioloalveolar stem cells (BASCs)
which lung cancer grows rapidly, metastasizes more slowly, produces keratin
squamous cell carcinoma
intercellular bridges, keratin pearls
squamous cell carcinoma
what is the most malignant, aggressive type of lung cancer?
small cell carcinoma
tx of choice for SCC?
chemo
which type is known to have a high N/C ratio?
small cell carcinoma
______is a dx of exclusion
large cell carcinoma
undifferentiated carcinoma with early metastasis and poor prognosis
large cell carcinoma
what type of lung cancer has the best 5 yr survival prognosis?
bronchioalveolar carcinoma
common causes of death in those with lung cancer (5)
- pneumona
- lung abscess
- bleeding
- esophago-pleural fistula
- effects of metastases on other organs
localized non invasive soft tissue tumor, attached to pleural surface by pedicle
solitary fibrous tumor
3 patterns of mesothelioma
- epitheliod
- sarcomatoid
- combo
