Nitroglycerin, isosorbide dinitrate Flashcards
1
Q
MOA
A
Vasodilates by releasing NO in smooth muscle
causing increase in cGMP and smooth muscle relaxation
Dilates vein» arteries
Decreases preload
2
Q
Clinical use
A
Angina, pulm edema
3
Q
Toxicity
A
Reflex tachycardia,
hypotension
flushing,
HA
4
Q
Monday disease
A
Development of tolerance for the vasodilating ation during the work week, and loss of tolerance over the weekend;
resulting in tachycardia, dizziness, and HA upon reexposure.
