Class III antiarrhythmics

Question 1

Definitions

Answer 1

K+ channel blockers

Names: amidoraone, ibutilide, dofetilide, sotalol

“AIDS”

Question 2

MOA

Answer 2

Increase AP duration
Increase ERP
Used when other antiarrhythmics fail
Increase QT interval

Question 3

Toxicity

Answer 3

Sotalol: torsa de pointes, excessive beta blockers
Ibutilide: tosade

Amio: pulm fibrosis, hepatotoxicity, hypothyroidism/hyper, corneal deposits, skin deposits (blue/gray) resulting in photodermatitis, neurologic effect, constipation, CV(brady, heart block, CHF)

Question 4

Special about amio

Answer 4

Class I, II, III, and IV effects because it alters the lipid membrane

Remember to check PFT, LFT, TFT for amio