Class II antiarrhythmics

Question 1

Definition

Answer 1

Beta blockers:

metoprolol, propranolol, esmolol, atenolol, timolol

Question 2

MOA

Answer 2

Decreases SA and AV nodal activity by
lowering cAMP, Ca2+ current
Suppresses abn pacemamkers by decreasing slope of phase 4.

AV node particularly sensitive: increase PR interval.
Esmolol very short acting

Question 3

Use

Answer 3

Ventricular tachycardia,
SVT
Slowing ventricular rate during Afib and Aflutter

Question 4

Toxicity

Answer 4

Impotence,
Asthma exacerbation
CV(bradycardia, AV block, CHF)
CNS effects (sedation, sleep alteration)
Many mask the signs of hypoglycemia

Metoprolol can cause dyslipidemia
Propranolol can exacerbate vasospam in Prinzmetal’s

Treat overdose with glucagon.