Nichols Last Minute 3: Cervix lesions, Triple negative BC, Breast cancer precursor lesions

Question 1

What percent of BC is triple negative?

Answer 1

15%

Question 2

Who is — BC more common in?

Answer 2

Blacks
Younger patients
Obese
More children at a younger age

Question 3

What percent of BC is — in blacks?

Answer 3

25% of BC in blacks <50

Question 4

What percentage of —BC is BRCA mutated?

Answer 4

20%: 70% of patients with BRCA1 get —BC

Question 5

What percentage of — is p53?

Answer 5

86%

Question 6

Epiodemiology of bad BC has what overlapping?

Answer 6

Triple negative
BRCA
Basal Like breast cancer

Question 7

What risk increase is there with usual ductal hyperplasia?

Answer 7

double risk of BC

Question 8

Buzzwords for usual ductal hyperplasia?

Answer 8

In Situ with:
Stretched twisted bridges
Heterogenous
Poorly defined borders
Irregular lumens "slit like"

Question 9

What is the risk increase with atypical ductal hyperplasia?

Answer 9

Five fold increase risk BC

Question 10

Buzzwords for atypical ductal hyperplasia?

Answer 10

In Situ:
Small uniform cells
Rounded nuclei
Cribriform lumen
Ridged briges (rounded and thick)

Question 11

What has more symptoms of cancer, atypical or usual ductal hyperplasia? Which one has more risk?

Answer 11

Usual: more cancer like
Atypical: more structure… but smaller

Atypical has more risk! (backwards thinking)