Histology of Female OB and Breast: Nichols Flashcards

1
Q

What are fragmented glands and stroma with degenerating blood indicative of?

A

Menstrual endometrium

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2
Q

What are the ant like cells in the menstrual endometrium? Why are they there? Why are they important?

A

x

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3
Q

What phase histology of straight glands line with pseudo stratified epithelium and stroma with spindle shape indicative of?

A
Proliferative endometrium:
Early
straight glands
PSSCE
Spindle stroma
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4
Q

What phase is prominent basal cytoplasmic vacuoles and glands indicative of?

A

Early secretory endometrium:

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5
Q

When does early secretory endometrium form?

A

36-48 hours post ovulation

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6
Q

What is histological evidence that ovulation has occurred?

A

Prominent basal cytoplasmic vacuoles:

Early secretory endometrium

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7
Q

What phase is tortuous dilated glands containing secretions seen in?

A

Secretory phase

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8
Q

Has the oocyte in the primordial follicle completed meiosis? Primary follicle?

A

No… stuck in Prophase I

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9
Q

What does the primary follicle have that the primordial follicles do not have?

A
Antrum
Stratum granulosum
Zona Pellucida
Theca: externa and interna
Cumulus ooporus
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10
Q

Where do androgens converted by granulosa cells come from?

A

Thecal cells

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11
Q

What stimulates granulosa cells to convert androgens to estradiol? By what enzyme?

A

FSH

Aromatase: during proliferative phase

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12
Q

What happens to granulosa cells after ovulation?

A
Become granulosa lutein cells 
Produce progesterone (instead of estrogen)
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13
Q

How would a granulosa cell tumor manifest in child? adult? after menopause?

A

x

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14
Q

What color is corpus luteum? corpora albicantia?

A

Luteum= yellow=fat

Albicantia=white=????

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15
Q

What happens to corpus luteum if fertilization occurs? If no fertilization?

A

Fertilized? hCG keeps it alive: progesterone: no menstruation
Not? it dies… menstruation

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16
Q

What is common with involution of corpus luteum?

A

Hemorhage

17
Q

What is a single layer of modified peritoneal mesothelial cells overlying stroma of spindle shaped cells on top of ovary?

A

Ovary serosa

18
Q

Why are 70% of ovarian tumors and 90% of malignant ovarian tumors from the serial surface?

A

xxx

19
Q

Why is the uterus not made of striated skeletal type muscle?

A

must stretch and adapt to pregnancy!

20
Q

What has a ciliated papillary epithelium and muscular wall in OB?

A

fallopian tube

21
Q

What is the transformation zone of the cervix?

A

Endocervix columnar with mucin
to
Exocervix stratified squamous

22
Q

Where does the transformation zone lie in childhood? after puberty?

A

Child: at external os
Puberty: out into os: ring of red is metaplastic SC zone

23
Q

What is another term for the transformation zone?

A

Squamocolumnar junction

24
Q

What is particularly prone to HPV infection?

A

Metaplastic squamous cells of transformation zone

25
Q

What are the two layers of the breast duct?

A

Luminal epithelial

Myoepithelial

26
Q

What are 90% of breast cancers?

A

Ductal

27
Q

What is the progression of breast cancer histology?

A
Hyperplasia
Metaplasia
Dysplasia
In Situ
Invasive
28
Q

Hyperplasia is contrasted to carcinoma in what histological way?

A

Hyperplasia: Basal myoepithelial cells are still in place

29
Q

How do pathologist see if basal myoepithelial cells are still in place?

A

Myosin immunostain

30
Q

What is the effect of progesterone on endothelium stroma?

A
DECIDUALIZATION: 
Spindle cells
to
Enlarged rounded cells with 
     abundant smooth pink cytoplasm
31
Q

What does endothelial large round stromal cells with large pink cytoplasm instead of spindle cells indicate?

A

Progesterone: Decidualization has occured