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Reproductive > Myometrium Physiology: Smooth Muscle: Young > Flashcards

Myometrium Physiology: Smooth Muscle: Young Flashcards

1
Q

Life is the maintenance of an ionic gradient. What is the dominant ion on the inside of the cell?

A

K

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2
Q

How does K get into the cell?

A

Na/K exchanger ATPase

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3
Q

What is the dominant member of a membrane?

A

Lipid

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4
Q

How thick is the membrane relative to the cell?

A

Like a basketball rubber thickness relative to cell

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5
Q

What causes shortening of the cell?

A

Actin and myosin shortening

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6
Q

What ion causes actin and myosin to shorten?

A

Ca+2

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7
Q

What is concentration of Ca+2 within the cell?

A

100 nanomolar Ca+2

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8
Q

What goes over the actin and interacts with Ca?

A

Calmodulin

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9
Q

Where does Ca come from to flood the cell?

A

Sarcoplasmic reticulum

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10
Q

What other mechanism raises intracellular calcium?

A

L type Dihydropyrodine Ca Channel: Ca Channel on membrane

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11
Q

What clinical drug inhibits L type Dihydropyridine Ca channel?

A

NIfedipine: Dihydropyridine blocker

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12
Q

What agonist modulates the 7 transmembrane receptor of the myometrial smooth muscle cell?

A
  1. Epi

2. Oxytocin

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13
Q

What is the 7 TM receptor coupled to?

A

G protein on inside

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14
Q

What is the name of the signaling compound activated by G protein?

A

IP3

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15
Q

Where does IP3 act?

A

Sarcoplasmic reticulum

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16
Q

What receptor does IP3 act on in SR?

A

IP3 receptor

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17
Q

What is the resting potential of a smooth muscle cell?

A

-40

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18
Q

What is the maximum voltage of a smooth muscle cell?

A

+10

19
Q

Where does Ca begin to enter cell in action potential curve?

A

Phase 2

20
Q

How does Ca get removed from cytoplasm?

A
  1. (SCRCA pump) ScR Ca ATPase pumps it back into SR
  2. Pumped out of cell by CaATPase on membrane
  3. Na/Ca Exchanger on membrane
21
Q

How does cell A communicate with cell B?

A

CONNEXIN 43: gap junction for electrical communication

22
Q

What is the stretch activated K channel?

A

When you stretch a cell, K leaves

23
Q

What happens with K leaves the cell?

A

Hyperpolarizes cell

Cell naturally depolarizes to threshold

24
Q

What is the threshold of the AP in the smooth muscle cell?

A

-35

25
Q

What happens when AP reaches threshold in sm cell?

A

Ca rushes in

26
Q

What is activated to release Ca from SR?

A

Ryanodine receptor

27
Q

How high does the Ca concentration increase from 100 nm resting concentration?

A

700-800 nm

28
Q

What happens when Ca concentration increases in cell?

A

Binds calmodulin

Reveals actin binding site, myosin slides across with ATP binding: CONTRACTION

29
Q

What pumps Ca back into the SR?

A

SRCA

30
Q

What allows Ca to exit cell?

A

Ca ATPase

Na/Ca exchanger

31
Q

How does smooth muscle relax?

A

Ca is pumped out of cell

32
Q

What causes tissue to contract?

A

Stretching

33
Q

How do you maintain membrane potential?

A

Leak and pumps

34
Q

Is there a DK channel in the uterine smooth muscle to allow Ca in and out of cell?

A

No… must be another one

35
Q

What is ROMK?

A

Volatage activated K channel

36
Q

What depolarizes membrane potential?

A

K channel: DK channel (delayed

37
Q

What starts all of these contractions?

A

Oxytocin!

38
Q

Does the uterine sm act as a syncytium?

A

Yes! Gap junctions: CONNEXIN 43

39
Q

What has to happen for myometrium to be ready to contract?

A

Make CONNEXIN 43
Make Calmodulin
etx… make the players

40
Q

How long does it take for myometrium to be activated?

A

7-10 days

41
Q

What from the baby goes to the myometrium of the mother to start activation of structural proteins there?

A

Protein A from surfactant

increases sex hormones in myometrium

42
Q

The relationship of the funduus to the cervix is almost exclusively due to?

A

Prostaglandins
Inflammation
(oxytocin in labor)

43
Q

This stuff is important… will you know it in your 3rd year?

A

Yes. Memorize it. Especially the attack points. And that it is redundant. There are 3 ways for Ca get out . Why? So that if one breaks, the others continue life on.

Reproductive (31 decks)

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