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Heme > NHLs > Flashcards

NHLs Flashcards

1
Q

older man with nonspecific symptoms of weight loss, anemic, easily fatigued. biopsy shows LNs with diffuse effacement containing small lymphocytes, admixed with larger activated lymphoctyes gathering in loose aggregates proliferating

A

CLL/SLL

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2
Q

most common cause of death in CLL

A

bacterial infections

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3
Q

older man with nonspecific symptoms of weight loss, anemic, easily fatigued diagnosed with CLL is now exhibiting swollen LN’s and splenomegaly.

A

Prolymphocyte evolution where CLL –> diffuse large B cell lymphoma, bad sign

survival drops to 1 year

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4
Q

markers for CLL

A

CD5, CD19, CD20, CD23, smudge cells, monoclonal lamda and kappa light chains indicating hypogammaglobulinemia

no ch translocations

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5
Q

CLL with smudge cells and spherocytes

A

autoimmune etiology

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6
Q

woman showing signs of an infection has a biopsy but it is returned showing disrupted LN architecture, lack of tingable body MOs in the germinal centers, monoclonality, BCL2 overexpression, but no CD5 expression

A

follicular lymphoma

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7
Q

characteristically takes the form of paratrabecular lymphoid aggregates

A

folliciular lymphoma

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8
Q

mortality and Follicular lymphoma

A

waxing and waning neoplasm

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9
Q

hallmark: 14; 18 translocation. What does this do?

A

BCL2 overexpressed in follicular lymphoma

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10
Q

predominantly nodular morphology and diffuse growth pattern observed in the LNs, within a network of reactive denderitic cells admized with macs and T cells. the majority of the cell population appear small with cleaved contours and scant cytoplasm, the remainers are large cells with open nuclear chromatin

what’s the memory hook for this?

A

follicular lymphoma: FL has 18 letters = t(14; 18)

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11
Q

BCL2+/BLC6 + / CD5 -

A

follicular lymphoma

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12
Q
  1. most common indolent B cell lymphoma
  2. most common B cell lymphoma overall
A
  1. folliciular lymphoma
  2. diffuse large B cell lymphoma
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13
Q

most common form of NHL

A

diffuse large cell b lymphoma

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14
Q

60 yo with ascites and indications of lymphoma (sweating, fever)

A

diffuse b cell lymphoma- KSHV/HHV8 type, malignant pleural effusion

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15
Q

someone who develops lymphoma after a bone marrow transplant

A

EBV type Diffuse Large B cell lymphoma

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16
Q

someone who develops diffuse large b cell lymphoma and has the MYC translocation

A

bad prognosis, worse than without

17
Q

single male, 60. biopsy: anaplastic cells that do not express B or T cell markers but have IgH clonal arrangements

A

KSHV subtype diffuse large cell lymphoma

18
Q

most commonly acquired mutation in DLBCL

A

BCL6 mutations that abrogate BLC6 activity

19
Q

the one be cell tumor that almost always fails to express BCL2

A

burkitt

20
Q

phagocytes have large abundant, clear cytoplasm, there’s a high mitotic index, involved tissues are effaced by diffuse infiltrate of intermediate sized lymphoid cells 10-25 micro meters in diameter w/round/oval nucleui, coarse chromatine.

bone marrow aspirates reveal clumped nuclear chromatin 2/5 nucleoli + royal blue cytoplasm contianing clear cytoplasmic vacuoles

A

burkitt lymphoma

21
Q

genetics of burkitts

A

chromosome 8 translocation involving c-MYC

c-MYC is a transcription regulator involved in upregulation of warburg effect enzymes

“chromosome 8 = C-Myc 8urkitt”

c mycburkitts

22
Q

fat stain reveals lot of fats in marrow biopsy

A

burkitts

23
Q

MCV < 80 fl

A
  1. microcytic anemia
    1. iron deficiency (late),
    2. ACD,
    3. thalassemias,
    4. lead poisoning
    5. sideroblastic anemia
24
Q

MCV 80-100

A

normocytic anemia (hemolytic and non-hemolytic)

25
Q

MCV > 100 fl

A

macrocytic anemia, megaloblastic and non-megaloblastic

26
Q

TAILS

A

microcytic anemia: thalassemia, anemia of chronic dz, Fe defiency, lead, sideroblastic anemia

Heme (24 decks)

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