hodgkins by marker

Question 1

EBV -

Answer 1

nodular sclerosis usually, lymphocyte predom, 40% of lympho rich

Question 2

CD15+ and CD30+

Answer 2

all of them except for lympho predom, CD15- and CD30-

Question 3

CD20+

Answer 3

only lympho predom

Question 4

F = M, most patients are young; M>F, peaks in younf adults and then again at 55 yo; M > F, older adults; young males with cervical/axillary LAD

Answer 4

1. nodular
2. mixed cellularity
3. lymphocyte rich
4. lymphocyte depleted
5. lymphocyte predom

Question 5

32 yo w/fever, painless LAD

Answer 5

think hodgkinL, nodular

Question 6

more commonly presents at stage I/II, free of systemic manifestations and is usually EBV-

Answer 6

hodgkin lymphoma nodular sclerosis AND hodgkin lympho predom

Question 7

more commonly presents at stage II/IV with constitutional symptoms such as fever and night sweats

Answer 7

hodgkin L mixed and lympho depleted

Question 8

staging of HL

Answer 8

nodal –> splenic –> hepatic –> bone marrow/other tissues

Question 9

immunophenotype of HL (specific gene, followed by traits in classical and non classical)

Answer 9

1. multiple copies of REL gene on Chrom 2 that upreg NfKB
2. Classical: CD15+, CD30+; if LOW in lymphocytes, EBV+
3. Non-classical (predom): CD20+, CD15- CD30-, EBV-