Mitomycine and Bleomycin

Question 1

generates alkylating agent that cross links DNA. what is my use?

Answer 1

mitomycin: limited to squamous cell cancer of the anus in combo with 5-HU

Question 2

dose limiting toxicity for bleomycin

Answer 2

pulmonary toxicity

Question 3

RFs for bleomycin

Answer 3

over 70
underlying pulmonary disease
received prior mediastirnal chest radiatino

Question 4

AEs of bleomycin

Answer 4

skin toxicity, pulmonary fibrosis, mucositis, alopecia

Question 5

bleomycin indications

Answer 5

Hodgkins + NHLs, germ cell tumors, H & N cancer, swuamous cell cancers of the skin, cervix, vulva

Question 6

bleomycin MOA

Answer 6

small peptide containing iron on one end and a iron binding domain at the opposite: binds DNA, double stranded breads, free radical formation,
causes DNA fragmentation- due to DNA-bleo-Fe(II) complex