Neurotransmitters & Precursors Flashcards

1
Q

phenylalanine

reaction

A

Phe -> Tyr

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2
Q

phenylalanine

enzyme

A

phenylalanine hydroxylase

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3
Q

what is NutraSweet and what does it interfere with?

A

D/L phenylalanine + aspartate (aspartame)
interferes with phenylalanine hydroxylase

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4
Q

tyrosine

catacholamines

A

Tyrosine->
- L Dopa
- Dopamine
- Norepinephrine
- Epinephrine

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5
Q

tyrosine

pigmentation

A

tyrosine -> melanin

enzyme = tyrosinase

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6
Q

what is missing in albinism?

A

melanin (have melanocytes)

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7
Q

tyrosine

thyroid hormones

A
  • inactive: T4 (thyroxine)
  • active: T3 (triiodothyronine)
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8
Q

T4 location

A

thyroid

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9
Q

T3 location

A

liver

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10
Q

T4 composition

A

2 tyr + 4 iodine

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11
Q

T3 composition

A

2 tyr + 3 iodine

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12
Q

how do T3 & T4 control metabolism?

A

make bigger and more mitochondria

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13
Q

tryptophan

products

A

serotonin
melatonin
niacin (B3)

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14
Q

tryptophan

serotonin reaction

A

Trp -> 5OHTrp -> 5HTP (5 hydroxytryptamine)

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15
Q

high levels of serotinin will cause…

A

increased bowel motility (diarrhea) + panic

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16
Q

low levels of serotonin will cause…

A

worry/depression + constipation

17
Q

changes in bowel motility indicates serotonin is…

A

produced in the gut

18
Q

histidine

reaction

A

histidine -> histamine

enzyme = decarboxylase (B1)

19
Q

histidine

functions

A
  • H1 receptors in capillary & hypothalamus = vasodilation & release ant. pituitary hormones
  • H2 receptors in parietal cells = release stomach acid
20
Q

glutamate

function

A

important excitatory NT in CNS (Mg is gate keeper)

Mg slows Na/Ca intake

21
Q

glutamate

excitatory reaction

A

binds to NMDA receptors

22
Q

glutamate is part of…

A

glutathione
SGPT

23
Q

glutamate

inhibitory reaction

A

glutamate -> GABA (helps focus)

requires decarboxylase, B1, B6

24
Q

function of glycine

A

inhibitory NT in skeletal muscle interneurons

25
Q

serine

reaction

A

serine -> choline

requires B6, B9 (folic acid), B12

26
Q

serine

choline reaction

A

choline + Acetyl CoA -> acetyl choline

27
Q

arginine

function

A

vasodilation

28
Q

arginine

reaction

A

arginine -> citrulline
(makes NO)