Lipid Peroxidation Flashcards
Name the 3 steps of lipid peroxidation
- initiation: formation of ROS
- propagation: ROS ^creation of other ROS
- termination: relies on antioxidants
name 3 ROS
- singlet oxygen: O2
- nitric oxide radical: NO
- hydroxyl radical: OH
the creation of ROS causes…
- free radical damage
- membrane permeablity
- DNA damage (nuclear & mitochondrial)
- creation of more ROS by lipid peroxidation
- oxidation of enzymes
termination of lipid peroxidation relies on ____
antioxidants
2 types of antioxidants
lipid soluble
water soluble
what recyles vitamin E?
vitamin C
what is the function of vitamin C?
recyles vitamin E
what is the most important lipid soluble antioxidant?
vitamin E
what is the most important water soluble antioxidant?
superoxide dismutase (SOD)
what is the reaction that SOD catalyzes?
(function of SOD)
O2 –> H2O2
converts ROS into hydrogen peroxide
location of superoxide dismutase
mitochondria: Mn SOD
Cytoplasm: CuZn SOD
where is NADPH made?
liver and red blood cells
detoxification of hydrogen peroxide requires ____
glutathione
- glutathione peroxidase
- glutathione reductase
where does the detoxification of hydrogen peroxide occur?
liver & RBCs
