Neuromuscular blocking drugs Flashcards
1
Q
what is the neurotransmitter at skeletal junctions
A
ACh
targets nicotinic receptors
type 1 - ion channel linked
2
Q
what is tubocurarine and how does it work
A
non-depolarising competitive antagonist of ACh
(neuromuscular blocking drug)
prevents action potential ignition at motor end plate
causes log dose curve to be shifted right
used during surgery
3
Q
what is suxamethonium and how does it work
A
neuromuscular blocking drug
extends EP depolarisation leading to depolarisation block
used as a muscle relaxant in ECT or for endotracheal intubation
4
Q
what are the unwanted effects of neuromuscular blocking agents
A
hypotension alterations in HR broncospasm apnoea excessive secretions
