Analgesia and anaesthesia Flashcards
1
Q
what are the types of opioid receptors
A
morphine
heroin
codeine (prodrug)
2
Q
what is the mechanism of opiates
A
they are depressants
cause hyperpolarisation bu increasing K ions and decreasing the inward current of Ca. This decreases adenylate cyclase activity
3
Q
how do local anaesthetics work
A
they are weak bases which work from inside the axon
the bind to the Na channel and block it. This reduces action potentials and therefore prevents the pain signal
4
Q
how do general anaesthetics work
A
reduce neuronal excitability and alter synaptic function by targeting the GABAergic system
5
Q
what is desirable in the blood:gas coefficient
A
a low coefficient - does not dissolve well in blood but more of it can cross the BBB
