Anxiety/sedation/depression

Question 1

what is the process of BAGA transmission

Answer 1

insert photo

Question 2

what is the effect of benzodiazepines on GABA transmission

Answer 2

increase frequency of channel opening

Question 3

what is the effect of barbiturates on GABA transmission

Answer 3

increase duration of channel staying open

Question 4

what are the main clinical uses of drugs targeting GABA

Answer 4

anaesthetics (barbiturates only) - thiopentone
anticonvulsants - diazepam, clonazepam, phenobarbital
anti-spastics - diazepam

Question 5

what is the monoamine theory of depression

Answer 5

depression is caused by a functional deficit of central monoamine transmission

NA and 5HT follow the levels of MA

(mania is an excess of MA)

Question 6

how do tricyclic antidepressants work

Answer 6

monoamine reuptake inhibitor
inhibits NA and 5-HT reuptake too

has sedation as side effect

Question 7

how do monoamine oxidase inhibitors work

Answer 7

inhibit monoamine oxidase which is responsible for breaking done monoamine
therefore increases stores of 5HT and NA

Question 8

how do selective serotonin reuptake inhibitors work

Answer 8

inhibit reuptake of 5-HT

fewer bad side effects therefore safer in OD however SSRIs are less effective in severe depression

prozac

Question 9

how does lithium work

Answer 9

mood stabilising but not anti-depressive