anti-microbials Flashcards
1
Q
what are the main classes of antibiotic drugs
A
protein synthesis inhibitors: nucleus acid synthesis DNA replication RNA synthesis protein synthesis
bacterial wall synthesis targeting drugs: peptidoglycan synthesis peptidoglycan transportation peptidoglycan incorporation cell wall stability
2
Q
what are the main mechanisms used by bacteria to become resistant to drugs
A
additional target sites hyperproduciton alteration in target enzyme alteration in drug permeation production of destructive enzymes
3
Q
name some examples of anti-fungals and what they target
A
azoles - fluconazole
polyenes - amphotericin
4
Q
how does a virus use the host cell too replicate
A
attachment and entry into cell
uses host cell machinery to replicate and integrate DNA
assembles and releases new viruses
5
Q
what are the mechanisms of drugs targeting HIV
A
ritonavir acts as booster to other drugs HIV entry inhibitors HIV replication inhibitors HIV integrase inhibitors HIV protease inhibitors
6
Q
what are the mechanisms of drugs targeting hepatitis
A
tenofovir - nucleotide analogue for Hep B
ribavirin - purine analogue
7
Q
what are the mechanisms of drugs targeting herpes
A
acyclovir - nucleoside analogue
8
Q
what are the mechanisms of drugs targeting influenza
A
neuraminidase inhibitor
