Neurology Flashcards
Valproic Acid
Use for generalized epilepsy (eg. Myoclonic seizures)
- Broad-spectrum
Carbamazepine
Use for partial seizures
- Narrow-spectrum
Phenytoin
All seizures and status epilepticus (NOT absence)
Membrane Permeability:
- Resting membrane potential:
- Ligand gated channel permeability: Na+
- Voltage gated channel permeability: Cl-
ALS compared to Polio
Loss of neurons in anterior horn (LMN) & atrophy of lateral corticospinal (UMN)
- Polio is only anterior horn damage
NE Breakdown
NE converted to E by methylation then E is methylated to Vanillymandelic acid (a metanephrine)
Autonomic postganglionic nerve:
Unmyelinated
Trigeminal Nerve Exits at _______
Mid-Pons
Facial Nucleus Located at ______
Caudal Pons
S-100+
Schwannoma
Melanoma
Langerhan’s Histiocytosis
Friedrich’s Ataxia
Spinocerebellar degeneration, kyphoscoliosis, pes cavus, hypertrophic cardiomyopathy
Timolol
Beta blocker to treat glaucoma by decreasing aqueous humor production by ciliary epithelium
Length Constant
Measure of how far along an axon an impulse can propagate
- Decreased by demyelination
Ring Enhancing Lesions in brain
Staph Abscess, Toxoplasma, or Primary CNS Lymphoma
Toxoplasma
- from undercooked meat (or cat feces)
- Treat toxoplasma with sulfadiazine and pyrimethamine
- Congenital (torch): macrocephaly and intracranial calcifications
Primary CNS Lymphoma
multicentric ring lesions
- MC CNS tumor in immunocompromised
Agnosia
- unable to recognize
- temporo-occipital cortex
Marcus-Gunn Pupil
swinging flashlight test, both dilate when light moved from normal to affected eye (not actually dilating, just less constricted because the affected eye can’t transmit signal as well)
Subacute Sclerosing Panencephalitis
May be caused by measles
Hypertensive Hemorrhage
(lenticulostriate aneurysms): MC in basal ganglia and internal capsule
Conduction Aphasia
arcuate fasciculus (cannot repeat, but is fluent and has full comprehension)
Optic Neuritis aw/:
MS (autoimmune disorder in which CD4 T cells react against myelin via cytokines like IFN gamma)
Tx for Status Epilepticus
- Benzodiazepines (lorazepam or diazepam) for active seizure
- Also give Phenytoin to prevent recurrence of seizures or if Benzo doesn’t work
Tx for Drug-induced parkinsonism
Benztropine and trihexyphenadyl
Carbon Monoxide
Necrosis of globus pallidus and substantia nigra
Lumbar puncture Contraindications
- High intracranial pressure
- Overlying infection
Oculomotor (3) Nerve Lesion
- no up, down, or medial, can’t constrict pupils
- Nerve runs between PCA and superior cerebellar arteries
- Isolated 3rd nerve palsy → think actively enlarging intracranial aneurysm
Abducens (6) Nerve Lesion
No lateral (lateral rectus)
Trochlear (4) Nerve Lesion
No slight down and in (superior oblique)
HIV Encephalitis
- multinucleated giant cells in microglial nodules
- w/ CD4 count
No Convergence w/:
Oculomotor (CN 3 ) palsy
but can converge w/ INO (MLF lesion)
Vertical Diplopia
- double vision going down stairs from a trochlear nerve palsy
- Superior oblique not working so must tilt head to see properly
Tongue Innervation: Motor, Sensory, Tasts
Motor: hypoglossal nerve (XII)
- Does all muscles except palatoglossus (done by vagus)
Anterior 2/3:
- Taste: chorda tympani of facial nerve (VII)
- Sensation: V3 branch of trigeminal
Posterior 1/3:
- Taste & Sensation: Glossopharyngeal
Most posterior aspect/epiglottis
- Taste and Sensation: Vagus
Alzheimer’s
decreased Ach levels (basal nucleus of meynert) due to deficiency of choline acetyltransferase
Innervation of Ear/Ear Canal
- Vagus (auricular branch): posterior external auditory canal
(May experience syncope if stimulated) - V2 (auriculotemporal branch): remainder of external auditory canal, external tympanic membrane
- Glossopharyngeal IX (tympanic branch): inner surface of tympanic membrane
- Stapedius is innervated by Facial Nerve (CN VII) which if paralyzed causes hyperacusis
Cochlea: High and Low Frequency Sounds
- Low Freq at apex (wide and floppy) near Helicotrema
- High Freq at base (narrow and rigid) near oval and round windows
Glaucoma Tx: reduce aqueous humor secretion by ciliary epithelium
Timolol, other non-selective Beta blockers, and Acetazolamide
Glaucoma Tx: Increased aqueous humor outflow
Prostaglandins and Cholinomimetics (contracting iris sphincter opens up path to trabecular meshwork)
Werdnig-Hoffman
(aka SMA, spinal muscular atrophy): floppy child, anterior horn damage
Tx for General Tonic-Clonic Seizure
Valproic Acid
Internal Capsule Lesion
Motor Deficit
Thalamus Lesion
Sensory deficit w/ some difficulty w/ proprioception
Pons Lesion
Pinpoint pupils, decerebrate rigidity, bilateral paralysis
Caudate Nucleus Lesion
Transient hemiparesis, chorea, dyskinesia, agitation, psychosis
Glucose infusion can exacerbate:
Thiamine deficiency
Hearing Loss: Rinne Test
Air should be louder than bone
- Abnormal suggests conductive hearing loss (in tested ear)
Hearing Loss: Weber Test
Sound should be equal on both sides
- Conductive: lateralizes to affected ear (due to diminished ambient noise)
- Sensorineural: lateralizes to unaffected ear (because impair ear can’t sense vibration)
POMC cleaved into:
ACTH, MSH, and B-endorphin (endogenous opioid)
Notochord forms at:
3 weeks (day 16)
Sympathetics to Sweat glands and Adrenal Medulla
Sympathetic send Ach to sweat glands (via post ganglionic nerve) and to adrenal medulla (preganglionic)
- Everything else is Ach preganglionic, and adrenergic postganglionic
Parasympathetic transmits via:
Ach
- Preganglionic is Nicotinic (ligand gated ion channel, fast)
- Postganglionic is Muscarinic (G ptn, slow)
______ contraindicated in Glaucoma
Anti-cholinergics
Raphe Nucleus
Serotonin
Locus Ceruleus
NE (Norepinephrine)
Nucleus Basalis of Maynert
Acetylcholine
Caudate Nucleus
GABA
Substantia Nigra
Dopamine
PCP: MC cause of death
Trauma, NOT seizures
Only sensory pathway that doesn’t pass through thalamus
Olfactory (smell)
______ should always be added to cover for Listeria in infants and immunocompromised
Ampicillin
Meniere’s Disease
Due to decreased absorption of endolymph in vestibular apparatus:
tinnitis, vertigo, and sensorineural hearing loss
Neural Tube –>
CNS (brain and spinal cord)
Neural Crest –>
PNS and leptomeninges
Notochord –>
Nucleus pulposis
Prosencephalon (forebrain):
Telencephalon: Cerebral hemispheres + ventricles
Diencephalon: Thalamus + 3rd Ventricle
Mesencephalon (midbrain):
Mesencephalon: Midbrain + Aqueduct
Rhombencephalon (hindbrain):
Metencephalon: Pons, Cerebellum, + Upper 4th ventricle
Myelencephalon: Medulla + Lower 4th ventricle
Gene aw/ Holoprosencephaly
SHH (sonic hedgehog) gene
Syringomyelia
usually bilateral pain and temp loss of upper extremity
- May also see Upper LMN signs and Lower UMN signs
Wallerian Degeneration
degeneration distal to injury and proximal axon retraction
Meissner Corpuscle and Merkel Discs
Superficial
Meissner: light touch, fast adapting
Merkel: pressure, slow adapting
Pacinian Corpuscle and Ruffini
Deep
Pacinian: vibration and pressure, fast adapting
Ruffini: stretch, slow adapting
Nucleus Accumbens
GABA
Neurotransmitters in Huntingons
Decreased GABA and Ach
Increased Dopamine
Neurotransmitters in Alzheimers
Decreased Ach