Neurocognitive disorders- exam 4 Flashcards

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1
Q

what does delirium mean

A
  • acute, short term, rapid onset
  • disturbance of consciousness: memory, disorientation, perception, attention & awareness (cant focus, sustain, or shift attention)
  • obviously due to a general medical condition or substance induced (medication, drug, or toxin)
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2
Q

does the word ‘acute’ apply to neurocognitive disorders

A

no, they are long term and chronic

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3
Q

how is delirium different from dementia

A

dementia is a neurocognitive disorder. people with dementia can have delirium but not everyone with delirium has dementia

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4
Q

what is sundown syndrome

A

symptoms of dementia/neurocognitive disorder worsen at night

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5
Q

what is ICU psychosis

A

patients in the ICU who develop delirium as a result of sensory isolation

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6
Q

what is cognitive functioning in normal aging

A

The normal aging process is associated with declines in certain cognitive abilities, such as processing speed and certain memory, language, visuospatial, and executive function abilities

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7
Q

what is crystalized intelligence vs. fluid intelligence

A

Fluid intelligence is your ability to process new information, learn, and solve problems. Crystallized intelligence is your stored knowledge, accumulated over the years. The two types work together and are equally important.

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8
Q

how is recall different from recognition

A

Recognition refers to our ability to “recognize” an event or piece of information as being familiar, while recall designates the retrieval of related details from memory

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9
Q

is recall or recognition more difficult in old age

A

recall

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10
Q

what happens to processing speed and attention as one ages

A

A hallmark of cognitive aging is slowed processing speed, or a decrease in the rate at which people perform perceptual, motor, and decision making tasks.

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11
Q

what is dementia; what are the primary signs and symptoms/DSM-5 criteria

A

multiple cognitive defects including:
- impairment in memory (multiple etiologies)
- function is impaired (interferes with indepence in daily activities)
- concern of a ‘knowledgeable informant’ or the individual of significant decline
- evidence of decline documented by neuropsychological testing or by another clinical professional
- evidence of ‘causative mutation’ from family or genetic testing

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12
Q

what are the multiple etiologies/several causes of nuerocognitive disorders/dementia

A
  • alzheimers
  • vascular
  • lewy body
  • prion disease
  • fronto-temporal
  • parkinsons
  • huntingtons
  • HIV
  • TBI
  • substance/medication induced
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13
Q

what is alzheimers, who first described it, and when

A

described by German neurologist Alois Alzheiemr in 1906
- progressive loss of brain tissue
- a leading cause of death in those over age 65 in US

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14
Q

what is agnosia

A

inability to interpret sensations and hence to recognize things

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15
Q

what is apraxia

A

difficulut preforming skilled movements (like walking)

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16
Q

what is aphasia

A

loss of speech and communication skills

17
Q

what/who is a knowledgeable informant

A

a family member/friend/caretaker who is worried about the patient and/or able to provide information about their cognitive decline

18
Q

how are neurocognitive disorders diagnosed in a doctors office

A

family histoyr, rule out other disoders that could be causing symptoms, brief exam of cognitive function

19
Q

what are the genetics for familial alzheimers (4 different chromosomes)

A

Chromosome 21:
- formation of beta-amdyloid precursor protein
- single amino acid substitution
- 50 different mutations
Chromosome 1 and 14:
- 75% of early onset cases- presenilin 1 and 2; affects breakdown of amyloid
- (presenilin: part of gamma-secretase; a transmembrane enzyme that processes/cuts proteins into soluble products)
Chromosome 19 (ApoE-4 allele)
- overproduction of beta-amyloid

20
Q

brain pathology involves what + what

A
21
Q

what are tau protiens

A
22
Q

what are neurofibrillary tangles and beta-amyloid plaques? where are they found? what is beta and gamma secretase

A
23
Q

what are detrimental and protective factors

A
24
Q

what are some acetylcholinesterase inhibitors

A

treatment of alzheimers
- cognex (tacrine)
- aricept (donepezil)
- reminyl, razadyne (galantamine)
- excelon (rivastigmine)

25
Q

what are some glutamate reulators

A

alzheimers treatment
- namenda (mentamine)

26
Q

what are some antidepressants

A

also used in treatment of alzheimers; SSRIs, etc.

27
Q

what are some anti-infalmmatories (how long before symptoms do you have to be on these)

A
28
Q

what are other treatments such as lifestyle changes involving care and oversight for neurocognitive disorders

A

using external memory aids and providing engaging in pleasant activities and exercise

29
Q

what is vascular dementia and how is its progression different from alzheimers?

A

vasucalr dementia is caused by impaired blood flow to the brain (stroke, blood clot, etc.)
alzheimers worsens with time where as the symptoms caused by vascular dementia stay the same