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THIRD YEAR > Neuro4 > Flashcards

Neuro4 Flashcards

1
Q

neutrophils in SAH

A

bacterial meningitis

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2
Q

viral encephalitis cause can be what

A

autoimmune

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3
Q

encephalitis ix

A

LP, EEG, MRI

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4
Q

inflamed temporal lobe on MRI

A

viral encph

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5
Q

neisseria meningitides found where
how does it get to meninges
what are the ump due to
who is vaccinated against this

A

throats of healthy carriers
bacteria -> meninges via blood stream
endotoxin
military recruiters vaccinated with purified capsular polysaccharide to prevent epidemics

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6
Q

HI influenza part of what
requires whats for growth
how many types
commonest type for under 4s

A

normal thorax bacteria
blood factors
6
HiB

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7
Q

cochlear implants risk

A

pneumococcus meningitis

rare but v high mortality

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8
Q

cryptococcal meaning risk
dx
rx

A

HIV
serum and CSF cryptococcal antigen
IV amphoterin B/flucytosine. fluconazole

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9
Q

what happens in children within 24-36 hours of antibiotic treatment in meningitis

A

CSF culture negative

no sig change in cell count/chemistry

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10
Q

brain is how much of body weight

A

2%

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11
Q

how much CO does brian use
carried o2
carried glucose

A

15%
20%
12%

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12
Q

saccular aneurysms are what

A

true aneurysms with involevemtn of all layers of the vessel

arise at arterial bifurcaition points

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13
Q

what allele predisposes to alzheimers with some cluttering in families

A

e4

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14
Q

e2 in alzheimers

A

assoc with longitivtiy

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15
Q

traumatic extradural haematomas

if unrx

A

tempoparietak region that involves middle meningeal artery

mediastinal shift

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16
Q

subdural haem acute

chronic

A

related to injury - clotted blood

liquified blood - brian atrophy

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17
Q

why are neurones more susceptible to damage

A

can’t use anaerobic glycolysis

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18
Q

webers syn damage

A

midbrain of breianstem

vertibrobasilar - post

19
Q

CRRK 2
parkin
GBA mutations

A

dom PD
recessive PD
greatest genetic risk for PD

20
Q

primary dystonia physio abnormality

A

loss/reduction ire ciprocal inhibition
alterations in brain plasticity
alterations in sensory function

21
Q

who grading for astrocytic tumours

A

1 piloycyctic, pleomorphic, xanthaastrocytomas, subependymal giant cell
2 low grade
3 anaplastic
4 glioblastoma multiforme

22
Q

pilocytic astrocytomas

A

more common in childhood

23
Q

oligodendroglial tumoruss

A

sensitive to chemo

24
Q

first seizure and driving

A

6m 5y if HGV/PCV

25
Q

epilepsy and driving

A

1y

10y off med for HGV/PCV

26
Q

watershed infarcts caused by

A

general hypotension

27
Q

why is ceft given first line in mening and not penicilline

A

longer half life

penetrates CSF better

28
Q

giving steroids in meningitis reduces what

A

longterm nerd cx

29
Q

PNS myelination

A

schwanna cells

30
Q

CNS myelination

difference

A

oligo

does multiple neurones at the same time

31
Q

stomping gait / sensory gait

A

dorsal column problem

32
Q

tysabri (rx for MS)

A

can cause AML

33
Q

highest cause of deaths in under 40s

A

glioblastomas

34
Q

GCT CT

A

iso or hyper dense

35
Q

MS brainstem symp

A

RVI diplopia

RVII facial weakness

36
Q

FXTAS MRI

A

T2 hypersensitivity in middle cerebellar peduncles

37
Q

confirm FXTAS

A

molecular testing

38
Q

chronic hereditary sensory motor neuropathy

A

CMTIa commonest - genetic testing

39
Q

MND

A

loss of motor neurones from cortex of brain

40
Q

AML

A

idiopathic

familial - gene on chromosome 21

41
Q

myotonia

A

failure of muscle relaxation after use

42
Q

myotonic dystrophy

A

trinucleate repeat disease with anticipation

43
Q

bosilism

A

cleave pre synaptic proteins involved in vesicle formation and block vesicle docking with pre synaptic membrane

THIRD YEAR (27 decks)

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