neuro oncology

Question 1

which antibodies are associated with opsiclonus myoclonus ataxia syndrome in adults with breast cancer?

Answer 1

Anti-Ri

Question 2

which auto-antibodies are are associated with opsiclonus myoclonus ataxia syndrome in adults with small cell lung cancer?

Answer 2

anti-Hu

Question 3

what are the 3 subtypes of diffuse astrocytoma?

Answer 3

fibrillary, gemistocytic and protoplasmic

Question 4

what grade are diffuse astrocytomas?

Answer 4

WHO II

Question 5

Do diffuse astrocytomas enhance with gad?

Answer 5

no

Question 6

which brain tumor has necrosis with pseudopalisading nuclei?

Answer 6

GBM

Question 7

which brain tumor has a fried egg appearance and have vessels that resemble chicken wire?

Answer 7

oligodendroglioma

Question 8

which brain tumors have rosenthal fibers?

Answer 8

pilocytic astrocytoma and pleomorphic xanthoastrocytoma

Question 9

what is a common location for pleomorphic xanthoastrocytoma?

Answer 9

temporal lobe

Question 10

what brain tumor has perivascular pseudo-rosettes?

Answer 10

ependymoma

Question 11

what brain tumor has Homer-Wright rosettes?

Answer 11

medulloblastoma

Question 12

which paraneoplastic antibody is positive in 50% of people with praneoplastic cerebellar degeneration? Which 2 cancers are most associated?

Answer 12

anti-Yo. Ovarian and breast carcinoma

Question 13

which paraneoplastic antibody is present in paraneoplastic optic neuropathy, and what cancer is it associated with?

Answer 13

anti-CRMP-5, lung cancer

Question 14

which paraneoplastic antibody is present in paraneoplastic retinal degeneration, and what cancer is it associated with?

Answer 14

anti-CAR, lung cancer, thymoma, RCC

Question 15

which paraneoplastic antibody is present in paraneoplastic subacute sensory neuropathy and neuronopathy, and what cancer is it associated with?

Answer 15

anti-Hu, small cell lung cancer

Question 16

which paraneoplastic antibody is present in Lambert-Eaton myasthenia, and what cancer is it associated with?

Answer 16

anti-voltage gated P/Q Ca channels. Small cell lung cancer.

Question 17

which paraneoplastic antibodies are present in paraneoplastic bilateral choreoathetosis, and what cancer is it associated with?

Answer 17

Anti-Hu and anti-CRMP-5. lung cancer.

Question 18

what mutation is seen in half of anaplastic astrocytomas?

Answer 18

p53

Question 19

what WHO grade is anaplastic astrocytoma?

Answer 19

III

Question 20

what is the most common astrocytoma in children?

Answer 20

pilocytic

Question 21

what who grade are pilocitic astrocytomas?

Answer 21

I

Question 22

what WHO grade are pliomorphic xanthoastrocytomas?

Answer 22

II

Question 23

what WHO grade are SEGAs?

Answer 23

I

Question 24

what mutation is common in oligodendrogliomas and predicts better prognosis?

Answer 24

1p19q

Question 25

what is the most common location for oligodendrogliomas?

Answer 25

frontal lobe

Question 26

are oligodendrogliomas positive for GFAP?

Answer 26

no

Question 27

which brain tumors have eosinophilic granular bodies?

Answer 27

pleomorphic xanthoacstrocytomas, gangliogliomas and pilocytic astrocytomas

Question 28

which brain tumor has a biphasic pattern of complact regions along with microcystic components?

Answer 28

polocytic astrocytoma

Question 29

which neurocutaneous syndrome is associated with ependymomas?

Answer 29

NF2

Question 30

where are most ependymomas in children?

Answer 30

infratentorial

Question 31

are spinal cord ependymomas more common in adults or children?

Answer 31

adults

Question 32

what WHO grade are most ependymomas?

Answer 32

II

Question 33

what age has a worse prognosis for ependymomas?

Answer 33

patients younger than age 3

Question 34

what type of ependymoma occurs exclusively at the filum termniale? What WHO grade is it?

Answer 34

myxopapillary. WHO grade I.

Question 35

What genetic deletions are ependymomas associated with?

Answer 35

22q

Question 36

which brain tumors can have cyst with mural nodule on imaging?

Answer 36

pilocytic astrocytoma Pleomorphic xanthoastrocytoma ganglioglioma hemangioblastoma

Question 37

where is the most common location for ganglioglioma?

Answer 37

temporal lobe

Question 38

which surface markers are present in the neuronal component of gangliogliomas?

Answer 38

synaptophysin, chromogranin, neurofilament

Question 39

what do neurocytomas stain positive for?

Answer 39

synaptophysin

Question 40

what is the most common location for neruocytomas?

Answer 40

intraventricular

Question 41

what WHO grade are neurocytomas?

Answer 41

II

Question 42

what tumor arises from arachnoid cap cells?

Answer 42

meningioma

Question 43

what genetic loss is common in meningiomas?

Answer 43

loss of Chr 22

Question 44

which neurocutaneous syndrome are meningiomas associated with?

Answer 44

NF2

Question 45

what is the most common primary neoplasm of the cerebellum in adults?

Answer 45

hemangioblastoma

Question 46

what WHO grade is hemangioblastoma?

Answer 46

I

Question 47

what percent of hemangioblastomas are associated with von Hippel Lindau syndrome?

Answer 47

25%

Question 48

what pineal tumor is more common in young adults, and is composed of uniform cells with low mitotic index?

Answer 48

pineocytoma

Question 49

what pineal tumor is more common in children, and is composed of round blue cells with necrosis and hemorrhage?

Answer 49

pineoblastoma

Question 50

what genetic deletion is associated with pineoblastomas?

Answer 50

11q

Question 51

what is the most common location of epidermoid cysts?

Answer 51

CP angle

Question 52

what is the characteristic MRI finding of epidermoid cysts?

Answer 52

restricted diffusion

Question 53

defects in what chromosome are associated with medulloblastoma?

Answer 53

17

Question 54

what gene amplification is associated with a poorer prognosis in medulloblastoma?

Answer 54

N-myc

Question 55

what age is associated with a poorer prognosis in medulloblastoma?

Answer 55

\< 3 years

Question 56

which brain tumor consists of areas with ganglion cells floating in mucin mixed with glial components?

Answer 56

DNET

Question 57

What WHO grade are DNETs

Answer 57

I

Question 58

what is the age distribution of craniopharyngioma?

Answer 58

bimodal (childhood and later adulthood)

Question 59

what grade are choroid plexus papillomas?

Answer 59

WHO grade II

Question 60

what tumor commonly arises from the clivus and contains physaliphorous chells?

Answer 60

Chordoma

Question 61

what are the 3 most common tumors to metastasis to the brain in order from most common to least common?

Answer 61

lung cancer \>breast \> melanoma

Question 62

which 5 metastatic cancers are most likely to hemorrhage?

Answer 62

1. melanoma 2. choriocarcinoma 3. non-small cell lung cancer 4. thyroid carcinoma 5. RCC

Question 63

which phase of schwanomas are called Anton A?

Answer 63

compact phase

Question 64

What is a Voracay body?

Answer 64

palisading configuration of elongated nuclei in schwanomas.

Question 65

what marker are schwanomas positive for?

Answer 65

S-100

Question 66

what neurocutaneous syndrome are vestibular schwanomas associated with?

Answer 66

NF2

Question 67

what type of tumor arises in the pituitary and consists of thin-walled lining of columnar cells with ciliated goblet cells?

Answer 67

Rathke cleft cyst

Question 68

what type of paraneoplastic antibody is associated with limbic encephalitis in young adults? What cancer is it associated with?

Answer 68

anti-Ma, testicular cancer

Question 69

what type of paraneoplastic antibody is associated with limbic encephalitis in older adults? What cancer is it associated with?

Answer 69

Anti-Hu, lung cancer

Question 70

what deletion indicates progression in anaplastic astrocytomas and glioblastomas?

Answer 70

p16