Neuro: Headaches, Haemorrhages & Oncology Flashcards
Severe orbital-temporal pain around eye
Short (30 mins)
10 - 30 X per day
Paroxysmal hemicrania
Management for Paroxysmal hemicrania
Idomethacin
Unilateral Red, swollen + watery eye Miosis (pinpoint pupil) Ptosis (Drooping of the eyelid) Nasal discharge/stuffiness Facial sweating Severe pain around eye
Once or twice per day
Last 15 mins - 2 hours per episode
Continue for 4 - 12 weeks
Cluster headaches
- triggered by strong smells / exercise
Acute management for cluster headaches
Triptans
- Sumatriptan
High flow O2
Prophylactic management for cluster headaches
Verapamil
Lithium
Prednisolone
Headache worse when upright
Associated with Marfan’s
Spontaneous Intracranial Hypotension
- due to CSF leak
- pachymeningeal (dural) enhancement on MRI
- conservative tx
Unilateral headache in trigeminal area
10 - 20 per day
30s each episode
Trigeminal neuralgia
“suicide disease” - as so painful
- 10% bilateral
Management of trigeminal neuralgia
Carbamazepine
Bilateral headache
“band around head”
Recurrent
Tension headache
Headache behind eyes and nose
Sinusitis
Scalp tenderness
> 60 years old
Associated with polymyalgia rheumatica
Giant Cell Arteritis “Temporal arteritis”
Pain at back of neck
Cervical spondylosis
Unilateral throbbing pain Preceded by prodrome + aura Lasts all day Resolves with sleep Nausea + vomiting Limb weakness
Migraine
Features of migraine aura
Transient hemianopia disturbance “jagged crescent”
Sparks in vision
Photophobia
- Develops hours before onset of pain
Triggers of migraine
CHOCOLATE
Chocolate Hangovers Orgasms Cheese + Caffeine Oral contraception Lie ins Alcohol (red wine) Travel Exercise
Acute management of migraines
Triptans (Sumatriptan) + NSAIDs
Metoclopramide
Prochlorperazine
Prophylactic management of Migraines
- Topiramate (avoid in pregnancy, risk of cleft palate)
- Propranolol (avoid in asthmatics)
- Riboflavin
Give when > 2 attacks per month
Management for menstrual migraine
Fovatriptan
Zolmitriptan
Excessive volume of CSF caused by an imbalance between CSF + absorption
Hydrocephalus
Child:
- Increased head circumference
- Bulging fontanelle
- Sunsetting or eyes (impaired upward gaze)
- Dilated scalp veins
Adult:
- Morning headache (or upon lying down)
- Nausea + vomiting
- Papilloedema
- Coma
Hydrocelphalus
Causes of hydrocephalus
Obstructive (non-communicating)
- tumours
- SAH
- aqueduct stenosis
Non-obstructive (communicating)
- Increased production of CSF (choroid plexus tumour)
- Failure of reabsorption at arachnoid granulations)
- meningitis
- post-haemorrhage - Normal pressure hydrocephalus
Enlarged ventricles in brain (4th) Normal ICP Dementia (reversible) Incontinence Disturbed gait
Normal pressure hydrocephalus
Investigations of hydrocephalus
CT
MRI
LP (not in obstructive as can cause herniation)
Acute management of hydrocephalus
External ventricular drain (EVD)
- drains to external bag
Long-term management of hydrocephalus
Ventriculoperitoneal shunt
- drains to peritoneum
Headache Blurred vision Papilloedema Enlarged blind spot Horizontal diplopia (CN VI palsy) Young overweight female
Idiopathic intracranial HTN
Risk factors for idiopathic intracranial HTN
Obesity Female Pregnancy COCP Steroids Tetracyclines Lithium Vit A
Management for idiopathic intracranial HTN
Weight loss Acetazolamide Topiramate Repeat LP Surgery - optic nerve sheath decompression - lumboperitoneal shunt - ventriculoperitoneal shunt
Irregular/ decreased RR
Bradycardia
HTN
Wide pulse pressure
Cushing’s triad
- seen in increased ICP
- pre-terminal event
Headache post LP
Low pressure headache
Management of low pressure headache
Caffeine + hydration
Investigation for increased ICP
Fundoscopy
- looking for papilloedema
Headache
Postural hypotension
Papilloedema
Increased ICP
Management of increased ICP
Controlled hyperventilation
Raise head to 30 degrees
Management of severe increased ICP
Prior to surgery
- IV Mannitol / furosemide
Surgery
Diagnostic criteria for migraines
5 + attacks
- need
Lasting 4 - 72 hours
- need
Unilateral Pulsating Painful Aggravated by activity -need 2/4
Nausea + vomiting
Photophobia + photophobia
- need 1/2
Not caused by another illness
Neuro red flags / when to review immediately
GCS < 13 on assessment GCS < 15 after 2 hours Seizure post trauma Focal neuro deficit > 1 episode of vomiting Suspected skull fracture - haemotympanum - panda eyes - CSF leak - Mastoid bruising "battle sign"
Neuro amber flags / when to review within 8 hours
LOC/ amnesia + > 65 years old Hx of bleeding/clotting disorder Dangerous mechanism of injury > 30 mins retrograde amnesia On warfarin
First line investigation in suspected brain haemorrhage
CT
Intraparanchymal bleeding
CT: bright hyper-dense lesion
Intracerebral haematoma
“Haemorrhagic stroke”
Risk factors for a intracerebral haematoma
HTN Aneurysms Atriovenous malformation Cerebral amyloid angiopathy Trauma Brain tumour Infarct
Intra-ventricular haemorrhages are seen in
Premature babies
Non-accidental injury in kids
Trauma to the side of the head - acceleration/ deceleration injury Lucid interval Increased ICP CT: Lens shaped
Extradural Haematoma “Epidural”
Haematoma associated with temporal bone fracture
Extradural Haematoma
Type of bleed from extradural haematoma
Arterial bleed
- middle meningeal artery
- between dura mater + skull
Complications of extradural haematoma
Can lead to tentorial herniation
Management of tentorial herniation
Parietotemporal Craniotomy
Haematoma of slow onset Fluctuating confusion/ consciousness Old age Alcoholism Anticoagulated Crosses suture lines CT: Cresent shape
Subdural haematoma
Hypodense present shape on CT
Chronic subdural haematoma
Type of bleed from subdural haematoma
Venous bleed
- bridging veins
- bleeds into the outermost meningeal layer
- around frontal and parietal lobes
Sudden onset Severe occipital "thunder clap" headache "Like getting hit on back of head by a baseball bat" Meningism - photophobia - neck stiffness Nausea + vomiting Coma/ sudden death Seizures Increased ST
Subarachnoid haemorrhage (SAH)
Causes of SAH
Intracranial aneurysm (berry aneurysm) = 85% - Ehler danlos syndrome - PCKD - Coarctatino of aorta Atriovenous malformation Pituitary apoplexy Arterial dissection Cocaine use Sickle cell anaemia
Investigation findings of SAH
CT: - bright hyperdense (acute bleed)
- basal cisterns, sulk, ventricular system - not picked up in 7%
LP: - increased RBC
- Xanthochromia (yellow CSF- bilirubin) - performed 12 hours after (RBC breakdown) - normal/raised opening pressure
Bloods: Hyponatraemia (SIADH)
Management of SAH
- Coiling of intracranial aneurysms
- Nimodipine (21 days)
- CCB
- Prophylaxis for vasospasm
Watch for - re-bleeding (10% first 12 hours)
- hydrocephalus - hyponatraemia
Cerebral perfusion pressure
Adults: > 70mmHg
Children: 40-70mmHg
Most common cancers that cause brain metastasis
Lucky brains become so kind
Lung Breast Bowel Skin Kidney
Increased ICP - Papilloedema Change in personality Vomiting Headache (worse on bending over)
Think brain tumour
- mass effect
Unilateral hearing loss Tinnitus Vertigo Absent corneal reflex Facial palsy
Vestibular schwannoma “Acoustic neuroma”
- 5% of Intra Cranial Tumours
- 90% of cerebellopontine angle tumours
- slow growing & benign
Vestibular schwannomas arise from what nerve
CN VIII
Bilateral vestibular schwannomas are seen in
Neurofibromatosis Type 2
Investigations for vestibular schwannomas
MRI: Cerebellopontine angle tumour
Audiometry
Histology: Antoni A/B patterns Verocay bodies (acellular areas surrounded by nuclear palisades)
Management of vestibular schwannomas
Surgery
Radiotherapy
Observation
Solid/cystic tumour of sellar region Derived from remnants of Rathke's pouch - Hormonal disturbance - Hydrocephalus - Bitemporal hemianopia
Craniopharyngioma
Most common paediatric supratentorial tumour
Craniopharyngioma
- also occurs in adults
Investigations for Craniopharyngioma
Pituitary blood profile
MRI
Management of Craniopharyngioma
Surgical
Tumour found in the 4th ventricle
Hydrocephalus
Ependymoma
Histology shows: Perivascular psuedorosettes
Ependymoma
Vascular tumour of cerebellum
Associated with von-hipper-lindau syndrome
Haemangioblastoma
Histology: Foam cells + high vascularity
Haemangioblastoma
Benign slow growing tumour
Common in frontal lobes
Oligodendroma
Histology: Calcifications with “fried egg” appearance
Oligodendroma
Tumour of the brain membrane
Arises from the dura matter + compresses
Meningioma
Tumour located at:
- falx cerebri
- superior sagittal sinus
- convexity
Meningioma
2nd most common primary brain tumour in adults
Meningioma
Histology: Spindle cells in concentric whorls + calcified psammoma bodies
Meningioma
Management of meningiomas
Observe
Radiotherapy
Surgical resection
Most common primary brain tumour in adults
Glioblastoma multiforme
- malignant
- Poor prognosis (1y)
MRI: Solid tumour with central necrosis + enhanced rim
Glioblastoma multiforme
Histology: Pleomorphic tumour cells border necrotic areas
Glioblastoma multiforme
Management of Glioblastoma multiforme
Dexamamethasone (for oedema due to disruption of blood brain barrier)
Post op chemo and radiotherapy
Most common primary brain tumour in children
Pilocystic astrocytoma
Histology: Rosenthal fibres (corkscrew eosinophilic bundle)
Pilocystic astrocytoma
Aggressive paediatric brain tumour
Arises in infratentorial compartment
Spreads through CSF
Medulloblastoma
Histology: Small blue cells, Rosette pattern, many mitotic figures
Surgical resection
Chemotherapy
Types of pituitary adenoma
Secretory
Non-secretory
Microadenomas (<1cm)
Macroadenomas (> 1cm)
Cushing’s features (Increased ACTH)
Acromegaly (Increased GH)
Bitemporal hemianopia
Pituitary adenoma
Cause of bitemporal hemianopia in pituitary adenoma
Compression of the optic chasm
(due to crossing nasal fibres)
Management of pituitary adenoma
Manage hormonal side of things
Surgical (transphenoidal resection)
Decreased GCS
Quadraplegia
Miosis
Absent horizontal eye movements
Pontine haemorrhage
- caused by chronic HTN