Drugs: Cardio + Diabetes

Question 1

Metformin should be reviewed and stopped at what eGFR?

Answer 1

Reviewed at: < 45

Stopped at: < 30

Question 2

Side effects of Amiodarone

Answer 2

Thyroid problems

Pulmonary fibrosis

Question 3

Cardio selective CCBS are contraindicated in

Answer 3

Heart Failure
Hypotension
Bradycardia

• as would cause heart block

Question 4

Side effects of Thiazide diuretics

Answer 4

Can precipitate gout

Question 5

MoA of statins

Answer 5

Inhibit HMG-CoA reductase which decreases intrinsic cholesterol synthesis

Question 6

Statins are contraindicated in

Answer 6

Pregnancy 
With macrolides (can induce myopathy)

Question 7

Monitoring in statins

Answer 7

LFTs at start, 3 months, 12 months

If transaminases are increases 3 x then stop statins

Question 8

Side effects of Sulfonylureas

Answer 8

Hypoglycaemia

Question 9

examples of sulfonylyreas

Answer 9

Glicazide

Question 10

2 examples of ACE Inhibitors

Answer 10

Lisinopril

Ramipril

Question 11

ACE Inhibitors are contraindicated in

Answer 11

AKI

Question 12

Example of loop diuretics

Answer 12

Furosemide

Question 13

MoA of Loop diuretics

Answer 13

Prevent reabsorption at the loop of Henle, acts on sodium potassium channel

Question 14

Calcium channel blockers are split into two types

Answer 14

Cardio-selective and dihydropyridines

Question 15

Name 2 examples of cardio-selective CCBs

Answer 15

Verapamil (highly-negatively inotropic)

Diltiazem (less inotropic)

Question 16

Name 3 examples of dihydropyridine CCBs

Answer 16

Amlodipine
Nifedipine
Felodipine

Question 17

MoA of dihydropyridine CCBs

Answer 17

Effect vascular smooth muscle more than the myocardium

Question 18

Side effects of dihydropyridine CCBs

Answer 18

Flushing
Headache
Ankle oedema