Nervous/Endocrine define Flashcards
Dysraphia
= an abnormal seam
= a general term used for abnormalities arising from defective closure of the neural tube or its subsequent separation from overlying ectoderm
Anencephaly
absence of the brain
Prosencephalic agenesis
failure of neural tube closure rostrally -> absence of the forebrain (prosencephalon) and structures derived from it (e.g. cerebral hemispheres and eyes)
exencephaly
the meninges, dorsal skull bones, skeletal muscles and skin fail to develop over the missing forebrain, so that the undifferentiated neuroectodermal tissue lies exposed or protrudes from the skull
meningocoele
dorsal midline defect in the skull through which protrude fluid-filled meninges sac
meningoencephalocoele
dorsal midline defect in the skull through which protrude brain within meninges sac
meningomyelocoele
dorsal protrusion of a skin-covered sac containing spinal cord within meninges through the defect
spina bifida
any abnormality of dorsal vertebral arch formation
myelodysplasia
malformation of the spinal cord
syringomyelia
a tubular fluid-filled cavity (syrinx) in the spinal cord
hydromyelia
dilation of the central spinal canal with excess cerebrospinal fluid (CSF)
arthrogryposis
crooked joint
scoliosis
lateral deviation of the vertebral column
kyphosis
dorsal deviation of the vertebral column (hump-backed)
lordosis
ventral deviation of the vertebral column
torticollis
twisting of the cervical vertebral column across its long axis
Holoprosencephaly
a spectrum of forebrain (prosencephalon) malformations which typically include agenesis or severe hypoplasia of the olfactory bulbs and tracts
cyclopia
there is a single large midline eye within a single orbit
microencephaly
an abnormally small (hypoplastic) brain
pachygyria
abnormally broad cerebrocortical gyri
microgyria
abnormally small and numerous cerebrocortical gyri
agyria/lissencephaly
lissencephaly = absence of cerebrocortical gyri
Hydranencephaly
lysis of brain tissue and subsequent phagocytosis -> a variable degree of cavitation of the cerebral hemispheres
Porencephaly
s a less severe form of cerebral lysis than hydranencephaly
Hydroencephalus
accumulation of excess cerebrospinal fluid (CSF) within the cranial cavity - common
cerebellar hypoplasia
- incomplete development of the cerebellum is a common congenital (or early post-natal) malformation in domestic animals
cerebellar abiotrophy
premature or accelerated atrophy of a normally formed cerebellum
Lysosomal Storage Disorders
lysosomal storage disorders (LSD) are conditions in which substrates derived from normal cell catabolism accumulate within lysosomes rather than being degraded by lysosomal enzymes
encephalitis
inflammation of the brain
myelitis
inflammation of the spinal cord
encephalomyelitis
inflammation of the brain and spinal cord
ependymitis
inflammation of the ependyma
choroiditis
inflammation of the choroid plexus of the ventricles
meningitis
inflammation of the meninges
leptomeningitis
inflammation of the leptomeninges
pachymeningitis
inflammation of the pachymeninges
Mydriasis
dilated pupil
Anisocoria
uneven pupil size as seen with unilateral lesions
enophthalmos
○ narrowing of the palpebral fissure due to loss of smooth muscle tone in the eyelids.
Ptosis
rotrusion of the third eyelid - due to lack of smooth muscle tone causing its retraction
Miosis
narrowing of the pupil due to failure of contraction of the pupillary dilator
anhydrosis
lack of sweating in most animals
nociception
- refers to the system that carries signals of damage; it is the physiological event that accompanies pain
- “Nociception is born in the dorsal horn, but we don’t call it pain till it reaches the brain”
Allodynia
centralised pain sensation following a normal non-painful stimulus
hyperalgesia
enhanced perception of pain
cerebral concussion
a clinical condition characterised by (usually) temporary loss of consciousness and reflex activity following sudden head injury
cerebral contusion
haemorrhage into the meninges and/or about superficial or deep cerebral blood vessels as a result of head trauma
cerebral laceration
physical tearing of brain tissue due to trauma
what is acute brain swelling (congestive brain swelling)
the swelling is due to increased blood volume within the blood vessels of the brain rather than the accumulation of extra-cellular or intra- cellular oedema fluid
excitotoxicity
hypoxia results in decrease ATP in neurons -> release glutamate -> excess release results in increase calcium into neurons -> further destruction of metabolism ->activation of catabolic enzymes -> neuronal death
stroke/ cerebrovascular accident
characterised by cerebral haemorrhage (from vascular tears) or infarction (focal ischaemic injury caused by vascular occlusion and reduced blood flow)
paresis
deficit of motor function
paraparesis
bilateral motor dysfunction of the pelvic limbs
paraplegia
loss of motor function to the pelvic limb
paralysis
complete loss of voluntary movement
hyperaesthesia
increased sensitivity of the skin
Nociception
perception of pain
ataxia
lack of coordination
mentation
degree of mental alertness
analgesia
abscence of the sense of pain
hypalgesia
decreased sense of pain
Hyperalgesia
increase sense of pain
nystagmus
when eyes move rapidly and uncontrollably
epilepsy
symptomatic, reactive, primaru (idopathic)
seizures
generalised - whole body affected
Chemosis
oedema swelling of the conjunctiva
hyphema
pooling of blood inside the anterior chamber of the eye
plegia
paralysis or absence of motor function due to neurological damage
paresis
weakness in muscle due to neurological damage
caudal fossa
the region of the brain behind the tentorium
Cranial fossa
the region of the brain in front of the tentorium
Tetraparesis/tetraplegia
- All four limbs weak or paralysed
Hemiparesis/Hemiplegia
- 2 limbs are weak or paralysed
General anaesthesia
a state of unconsciousness , produced by drugs, with absence of pain sensation over the entire body
Obtundation
depressed response to stimuli (intracranial disease
Dysphoria
inappropriate reaction to surrounding environment which may include hyperexcitability, vocalising inappropriately
Stupour
lack of response to all but noxious stimuli