EPI 2 Flashcards

1
Q

Salmonellosis in humans, how many are contributed to a source, what type of salmonella most commonly involved

A
  • 54 /100,000 people per annum
  • ~93% cases are not attributed to a source
  • Salmonella Typhimurium
  • 48% of human cases
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2
Q

What are the 2 main hazards associated with eggs and describe

A
  1. Microbiological
    - Salmonella spp.
  2. Chemical and Physical
    - Agricultural and Veterinary Chemicals
    - Feed and food Additives
    - Plant, fungal and feed toxins
    - Processing aids
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3
Q

What are the main differences in chicken industry structure between meat and egg industry and how many males to female ratio

A
  1. Chicken Meat Industry
    - Vertically Integrated
    - Produce chicken meat for human consumption
  2. Chicken Egg Industry
    - Independent Farms
    - Produce eggs for human consumption
    1 male: 10 females
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4
Q

What are the different stages/structures in poultry industry

A
Breeding Stock
- Primary Breeding Companies
Poultry Company Structure
- Breeder Rearing*
- Breeder Production*
- Hatchery*
- Broiler or Layer Production
- Processing Eggs or Meat
- *Feed Mills
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5
Q

What are the 2 main types of transmission of salmonella in poultry

A

1) Horizontal transmission Oral – faecal
2) Vertical transmission – true or paravertical
○ True vertical - via ovarian contamination of white or yolk
○ Paravertical – via infection egg shells

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6
Q

List some clinical signs and postmortem lesions of salmonellosis of poultry

A
Clinical Signs
- Clinical presentation varies depending on:
- Age at infection, dose, serotype and strain
- May be absent
- Pasted vent
- Depression, anorexia
- Stunting
Postmortem lesions
- Pericarditis, perihepatitis
- Unabsorbed yolk sac
- Focal necrosis in liver
- Enteritis
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7
Q

What are 7 main sources of salmonella in chickens

A
  1. People
    1. Pest animals/insects
    2. Equipment
    3. Sheep - carryover
    4. Bedding material
    5. Feed
    6. Live birds
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8
Q

What is the most important source of salmonellosis in poultry, what occurs

A
  • Primary source of many Salmonella spp. serotypes
    ○ Not Salmonella free
  • Contamination is not evenly distributed within feed
  • Evidence that plants actively infected with Salmonella spp.
  • Farmers have little control over feed quality
  • Sampling is difficult
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9
Q

On farm sampling what is involved

A
  • Shed Design influences the way we sample
  • Environmental samples reflect flock infection
    ○ But may also be carry over from previous flock
  • Sample types include
    ○ Boot swabs
    ○ Dust swabs
    ○ Manure /mamure belt swabs
    ○ Egg belt swabs
    ○ Litter
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10
Q

What is some prevention and treatment of salmonella in poultry

A
Prevention
- Identification of infected flocks
- Culling of infected breeding flocks
- Vaccination 
Treatment
- Antibiotics may be used
○ But contra-indicated
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11
Q

Vaccination for salmonella in poultry what are the 2 types and what does it actual do

A
1) Modified live vaccines
○ Poor at best
○ Spray or oral drinking water
2) Killed vaccines
○ Autogenous
○ Proprietary
○ Intramuscular
- Used in combination to provide longer duration of immunity and protection
- Reduce duration and quantity of Salmonella spp. shed but do not prevent infection or shedding
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12
Q

Farmers responsibility what must we and what we must not do

A

Must
- Ensure premises, equipment and transportation
○ Constructed to minimise contamination of eggs
○ Kept clean, sanitised and in good repair
- Not supply eggs from birds affected by disease making eggs unsafe or unsuitable
- Identify and control safety hazards
- Ensure feed is not contaminated
Must NOT
- Sell eggs unless each egg is marked with producers ID
- Sell liquid white or yolk unless it is processed

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13
Q

What are the 3 things that lead to unacceptable eggs

A

a) a cracked egg or a dirty egg; or
b) egg product which has not been processed
c) egg product which contains a pathogenic microorganism, whether or not the egg product has been processed

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14
Q

What are 5 main ways for farm salmonella control

A

1) vaccinate flocks
2) depopulate infected flocks -> replace with non-onfected flocks clean and disinfect sheds
3) wash eggs - don’t wash inside, cross-contamination is possible with this process, water temperature needs to be higher then inside to keep water out
4) pasteurise all eggs from the flock
5) cangle - remove cracked and dirty eggs

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15
Q

Egg pasteurization does it occur in australia, why, what is needed

A
  • Small number of organisations in Australia
    ○ Whole Egg pasteurisation in USA routinely
    ○ Not in Australia
  • Little demand
  • Poor availability
  • Egg and Egg Products is the only thing that is done in Australia -> not whole egg
  • Reduction is time, temperature and dose dependent
    ○ 60 degrees for 3 minutes
  • Nothing is perfect
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16
Q

What are the 4 main factors that impact food system resilience

A
  • Unprecedented loss of biodiversity (and thus less resilient ecosystems)
  • Emergence of new infectious and non-infectious diseases
  • Climate change, weather variability and rising ambient temperatures globally
  • Increasing human population
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17
Q

What is important in terms of food security for the world and define

A

THEREFORE NEED A MOVE FROM JUST FOOD SECRUITY TO FOOD AND NUTRITION SECURITY
Definition
- When all people at all people have physical, social and economic access to food, which is consumed in sufficient quantity and quality to meet their dietary needs and food preferences, and is supported by an environment of adequate sanitation, health services and care, allowing for a healthy and active life. (CFS 2012

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18
Q

Non-communicable disease what is happening

A
  • Growing concern for animal and human health and wellbeing
  • Frequently related to poor dietary choices or formulations
  • Associated with food loss and waste
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19
Q

Emerging infectious disease what are the 3 things that their evolution is facilitated by and the main pathogen involved

A
  • Most are viruses, especially RNA viruses
    Pathogenic evolution facilitated by
  • Increased host population density
  • Increased genetic uniformity of host
  • Population increased contact rate between hosts
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20
Q

Evolution of avian viruses what are the 3 things they are facilitated by

A
  1. Host genetic homogeneity
  2. High density rearing - close to close animal to animal contact and favouring transmission of virulent over low pathogenic strains
  3. Intensive vaccination programs - provide selective immune pressures and may be executed improperly in resource poor settings
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21
Q

List 3 diseases that have emerged in poultry and 3 in pigs from intensive products

A
Poultry 
- Avian influenza 
- Newcastle disease 
- Diseases of increasing virulence -> Marek's disease 
Pigs 
- Classical swine fever 
- Porcine reproductive and respiratory syndrome 
- Influenza A subtype H1N1
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22
Q

Impact of HPAI (H5N1) pandemic what has occurred in terms of animal death and economic losses

A
  • Millions of poultry were slaughtered to control the spread of disease
    Ø 50 million domestic birds slaughtered in Vietnam alone
    Ø Widespread culling of family poultry impacted on vulnerable households
    ○ Increased stunting in children <5 years in Egypt
    Ø Economic losses in SE Asia totalled around US $10billion -> direct and indirect effects on food security
    ○ Some farmers loss of all animals with zero compensation
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23
Q

Give some examples of non-communicable diseases

A
  • Head, lung, liver, kidney and digestive tract disease
  • Diabetes
  • Cancer
  • Arthritis
  • Degenerative central nervous system disease
  • Genetic disorders
  • Autism
  • Mental illness
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24
Q

What is the focus of global nutrition

A
  • Interrelationships between farmers, gatherers, traders, regulators, consumers and policy-makers
  • Contributions to the sustainable production of animal source foods through biosecurity, animal welfare, animal health and production and environmental impact assessments
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25
Q

What are the 4 definitions of emerging infectious disease and give an example for each

A

1) infectious disease where incidence has increased
Eg - tuberculosis
2) infectious disease where the geographical distribution has changed
Eg - west nile virus
3) evolving infectious disease - old with new host (equine influenza in dogs) OR old with new presentation (Zika virus)
4) New discovered infectious disease (lyme disease caused by tick-borne borrelia)

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26
Q

Define a reservoir, what are they needed for

A
  • an ecological system in which the infectious agent survives indefinitely
  • Reservoir hosts are essential to the maintenance of the pathogen.
  • Without the reservoir host, pathogens would disappear, along with the disease that they cause.
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27
Q

what are the 3 main phases of virological discovery for bats

A

1) when scientists first identified a link between bats and viruses
2) when scientists went into the forest
3) when bats came out of the forest - hendra

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28
Q

What is important about geography with pathogen, vectors and spillover

A
  • an ecological system in which the infectious agent survives indefinitely
  • Reservoir hosts are essential to the maintenance of the pathogen.
  • Without the reservoir host, pathogens would disappear, along with the disease that they cause.
29
Q

What occurs with closely related bats

A

Closely related bats harbour closely related viruses

30
Q

In terms of public health and trade what was the cost of SARS outbreak in 2003

A
• > 8000 human cases	• 774 fatalities
	• cost to one Canadian hospital was $12 million
	• overall global cost = USD$30 billion
		○ due to high case morbidity rate
		○ trade and travel widely affect
31
Q

What are the 3 R’s of EIDs and describe

A
• REFINE our knowledge
- reservoir host – physiology, immunology etc.
- mechanisms of transmission
- disease ecology
• REDUCE opportunities for spillover
- epidemiology, conservation management
- public health education
• RESTORE populations and habitats
- biodiversity
- environmental management
32
Q

Hendra transmission how to prevent bat to horse transmission, horse to human transmission

A
Bat to horse 
- cover feed and water
- fence of fruiting/flowering trees
- stable overnight 
- vaccination 
Horse to humans 
- hand hygiene 
- use of PPE
- isolate sick horses 
- seek vet advise
33
Q

Hendra research what approach can be applied and how

A
  • Qualitative and quantitative research
  • Documenting opinions, emotions
    ○ Conduct via surveys (quantitative) and interviews (qualitative)
34
Q

What are the 2 ways to structure a qualitative interview

A
  • Aim to get people talking
    1. Informal, unstructured way can be done
    2. Semi-structured interview
    ○ Have a list of key questions and topics but can change the order in which you ask to flow with the conversation
    § Open ended question
35
Q

what are the 5 steps in analysing transcript from interviews

A
  1. Reading and re-reading of transcripts
  2. Developing a coding frame
  3. Data coding - ideally have at least 2 people doing this step
  4. Identify patterns and themes
  5. Conceptual model
36
Q

How to report qualitative research and what were the main motivators, barriers and perception of HeV risk in the hendra study

A
Report via quotes
Motivators 
- Protection of horses and people
- Increased biosecurity
- Responsible for the lives of others 
-Peace of mind 
Barriers 
- Costs 
- Efficacy 
- Applicable 
- Decrease freedom of choice - vets saying you must vaccinate 
Perception of HeV as a risk 
- Depends on personal experience 
- Severity and likelihood 
- Demographic characteristics 
- Awareness and knowledge
37
Q

What were some conclusions from the hendra virus research

A
  • 75% of horse owners have medium-high level of biosecurity, but…
    …discrepancy between assessed and self-rated level of biosecurity indicates different perceptions/definitions
    …respondents might be more engaged and represent “best case” compared to Australian horse owners in general
  • higher level of biosecurity seems to be influenced by awareness (location & HeV as potential DDx)
  • influence of property management is low…
    … feasibility of recommended measures (e.g. water dam, trees for shade)?
    Targeted communication and continued messaging around biosecurity & HeV risk mitigation via veterinarians
38
Q

List 9 main imapcts of EADS

A
  1. Animal health and welfare
  2. Economic – income, export markets, response costs, time to regain market access
  3. Livestock production
  4. Food security
  5. Human health
  6. Social
  7. Political
  8. Environmental
  9. Indirect - transport, trade, feed suppliers & rural tourism
39
Q

Government responsibilities in Australia in preventing emerging disease (australia and state/territory government)

A
- Pre-border/border - Australian Government 
Leadership on national priorities
○ Quarantine
○ Export certification
○ Trade negotiation
○ International disease reporting
○ Regional off-shore activities
- Post-border - state/territory governments 'Disease control and eradication
○ Disease surveillance and investigation
○ Animal welfare compliance
○ Food safety
○ Livestock traceability
○ Veterinary public health
40
Q

What are the 4 main roles of veterinarians

A

1) preparedness
2) prevention
3) response
4) recovery

41
Q

What is involved in preparedness and prevention in disease responses what is involved

A
  • Predetermined response plans and arrangements
  • Training/ exercising
  • Surveillance
  • Communications
  • Border control
  • Off-shore activities
    “Prevention is better than a cure”
    “Hope for the best, plan for the worst”
42
Q

What are the 5 key control principles for outbreaks

A
  1. Defining the problem
  2. Surveillance & tracing
    ○ Potential spread of the disease and the possible origin of the disease
  3. Quarantine & movement controls
  4. Disease elimination
    ○ Culling
    ○ Vaccination
  5. (Proof of freedom)
    ○ Undertake further work to prove Australia is free of the disease
    § Possible serological testing of herds
43
Q

Response arrangements in an disease outbreak what is involved in terms of agreement, what plan used and how maintained

A
  • Responses to Emergency Animal Diseases (EADs) are subject to a national cost-sharing agreement – Emergency Animal Disease Response Agreement (EADRA)
  • Costs are shared amongst governments and industry according to an agreed formula
    ○ Response agreement -> all industry bodies are signed up to this plan -> no need for negotiation during disease outbreak
  • Diseases are dealt with according to a predetermined plan (AUSVETPLAN, AQUAVETPLAN)
  • Plans are maintained by Animal Health Australia
44
Q

List 9 challenges of organizing an emergency animal disease response

A
  1. Response duration
  2. Resourcing / funding
  3. No two responses are the same
  4. Zoonotic disease risks
  5. Economic and social costs
  6. Animal welfare
  7. Public perception
  8. Need for ongoing staff training
  9. Changing biosecurity risk profile
    Climate, trade, travel, and use, encroachment into wildlife habitats
45
Q

List 4 main primary legislation acts in Victoria: involving veterinary public health

A

1) livestock disease control
2) prevention of cruelty act to animals
3) food act -> illness caused by foot that originated from agriculture farms in Australia
4) veterinary practice act

46
Q

What are 3 main groups of laws and describe what the involve in emergency animal disease

A

1) Law o prevent disease outbreaks -> specific provisions to prevent certain disease (swill feeding ban), restricting on working with disease agents
2) law to support early detection of disease outbreak -> compensation arrangements to support early reporting, animal identification and traceability (record keeping), support veterinary investigations
3) laws to control and eradicate disease outbreaks -> control the movement of animals, have power to quarantine property, kill animals, test and shut down an area

47
Q

Anthrax outbreak what are 3 things you want people to do and 5 things to government vets need to do

A

What do we want people to do?
- Report suspicion of disease
- Move animals away from contaminated areas
- Identify vaccinated animals
What do government vets and other officers need to do, with support of the law?
- Examine animals & collect diagnostic samples
- Examine records and collect information on animal movements and other movements
- Hygienic disposal of carcasses
- Cleaning and disinfection of infected premises and contaminated vehicles, equipment
- Vaccination.

48
Q

What occurs after notification of an emergency animal disease

A
  • CVO notified
  • Interstate/International reporting obligations
  • (Local and State Control Centres)
  • Quarantine, Movement Restrictions - Stock Standstill
  • Surveillance
  • Tracing
  • Communications – industry, media, etc.
  • Disease ‘elimination’ – vaccination, culling
49
Q

Incident management in emergency animal disease what are the 5 main areas

A

1) Public information
2) planning
3) operations
4) logistics
5) finance and administration

50
Q

Planning in an emergency animal disease response what is involved

A
  • Predict the future of the response based on current information and knowledge of the pathogen
  • Capture, synthesize and disseminate response data
  • Develop operational and resource plans
  • Contingency planning
51
Q

Operations (doers)in an emergency animal disease response what is involved

A
• Investigations (Look) 
- Tracing &amp; Surveillance
- Laboratory
• Restricted Area Movement and Security (Lockdown) 
- Permits, Checkpoints
- Mobile patrols
• Infected/Infested Premises Operations (IPOPs) (Clean-up)
- Valuation, Destruction,
- Disposal, Decontamination
52
Q

Logistics (getters) in an emergency animal disease response what is involved

A
  • Go to / Can do
  • Establishes and manages the LCC facility
  • Acquires, logs and tracks all resources
  • Arranges meals, beds, stores and equipment
  • ike vet nurses
53
Q

What are the 3 main phases of a response

A

1) investigations and alert
2) operations
3) stand-down

54
Q

Investigation and alert phase of an emergency animal response what are the 3 steps

A

1) Investigation team to confirm species identification & obtain samples
- Authorised officer & technical expert
- Follow evidence procedures
2) Initiate hygiene protocols
- property owner & response staff
3) Record urgent trace backs (source of infection) and trace forwards (potential spread)

55
Q

Operations phase of an emergency animal response what is it, 6 things it includes and the 3 D’s

A

Response plan has been approved & the eradication determined to be technically & economically feasible
- Eradication is priority
- Resources may be from multiple agencies and industry
May entail:
1. set up incident management centre/s and team/s
2. quarantine and eradication/decontamination of infected premises
3. restricted trade movements and product certification
4. treatment and/or destruction
5. value assets for destruction
6. government, business and community media liaison
3D’s
1. Destruction
2. Disposal of carcasses
3. Decontamination of equipment and facilities

56
Q

Stand-down phase of an emergency animal response what are the 4 steps

A
  1. Response effective
  2. Pest/disease not confirmed
  3. Pest/disease not eradicable
  4. Eradication not beneficial or cost effective
57
Q

White spot of prawns main sign, what species worse and why bad for australia and way to eradicate

A
  • Dying prawns gather on the surface and picked up by fishing birds – infective shells are vomited up.
  • White spot is worst in Tiger prawns -> Australian market is built on this therefore highly susceptible
  • destock infected farms, water, ponds, control movement from logan area, look for establishment in wild stocks
58
Q

What is the difference between bird flu and avian influenza and the clinical signs

A
  • High Path Avian Influenza causes viraemia and multiple organ failure not URTI.
  • Ovary are affected -> decrease in egg production on of the earliest sign
  • Death quickly -> large amount with outbreak can be 12,000
59
Q

How does highly pathogenic avian influenza occur (what is teh calssic rpcoess)

A
  • High Pathogenic Avian Influenza needs to be ‘selected’ to affect different species:
  • The classic process is:
    ○ Low Path virus carried in wild birds – may kill some but usually not.
    ○ Transferred by contact to domestic geese, ducks, chickens. Direct contact or faeces will do it.
    ○ Highest risk of contact is usually Free range. But probably low death rates in this situation (as seen in Cowra) … easy to miss.
  • The virus needs to adapt/select to the new host therefore quick transmission occurs in large population
60
Q

What are 3 things vets can do to decrease the risk of high pathogenic avian influenza

A

1)- Get yourself a flu vaccine this season if you work with birds or pigs.
○ This decreases the chance of recombination happening but it will not protect you.
2) Keep a distance between free ranging animals and intensive animals on farms.-
3) Decrease chicken contact with wild ducks and their faeces.

61
Q

What were the 7 main impacts of the 2001 UK FMD outbreak

A

1) Political
2) media
3) livestock industry
4) export markets
5) countryside access
6) social
7) environmental

62
Q

With the 2001 FMD outbreak what is involved in the political, media and livestock industry impacts

A
  1. Political
    - Delay of general election,
    - Electoral dissatisfaction
    - Public enquiries
  2. Media
    - want hourly update
  3. Livestock industry
    - Loss of genetic material
    - National movement ban - rapid overcrowding particularly pigs
    - Long term restrictions - over condition, additional feed costs for those who cannot transport their animals
    - Transport availability -
    - Restocking - introduction of endemic disease
    - Red meat industry - closure of abattoirs, reduced demand, vaccination
63
Q

With the 2001 FMD outbreak what is involved in the export market and countryside access impacts

A
  1. Export markets
    - Loss of live animal exports
    - Loss of animal product exports
    ○ Lamb/beef/dairy products/wool (act as a fomite and spread disease)
    ○ Regaining markets
    ○ Regaining market share -> when you were gone other countries fill in the gap
    ○ Damage to reputation
  2. Countryside access
    - Restriction led to perception that countryside was closed
    ○ Economic impact greater than farming impact
    - Damage to tourism -> foreign visitors, displacement
    - Impact on sport -> horse racing, international rugby, field sports
    - Difficult to re-open country side
64
Q

With the 2001 FMD outbreak what is involved in the social and environmental impacts

A
  1. Social
    - Emergence services (vets) - long hours, stressful work, not supported by public, impacts on families/long-term impacts
    - Farmers - loss of generations of work, financial, inequalities in compensation (if you did have disease would get compensation but if you didn’t then still couldn’t sell and had to feed, over-crowding)
    - Wider rural community - disruption to businesses, fear of disease, schools/universities
  2. Environmental
    - Need to dispose of a large number of carcasses
    - Pyres - public resistance, health concerns, disposal of ash
    - Burial - ground water contamination, engineering challenge, long-term management
    - Rendering - best solution environmentally - transport, bisecruity, capacity
    - Disinfection - large quantalities
65
Q

What are the 3 main important factors of anthrax and what test can use in the field

A

1) Public health
2) Effect on exports sale or land
3) Direct cost on farmer
Anthrax immunochromatographic test
- Point of care screening test
- Used in the field as part of an investigation of suspected anthrax in a livestock carcass
- Takes 15 minutes
- Cattle -> good sensitivity, sheep not a lot of formal
- Like a pregnancy test, 2 lines have anthrax

66
Q

Bio-security what are the 5 steps in moving out of a secruity zone

A
  1. Move into detergent tub
    - Gross clean boots, gloves
  2. Move into disinfectant tub
    - Scrub gumboots, and gloves
  3. Removal of overalls by rolling so outside comes in, removal of gloves all layers within the disinfectant tub
  4. Overalls in the garbage bag with gloves
  5. Last step is to remove ventilator (if need to wear one for human health issue)
67
Q

What is involved in the AUSVETPLAN for equine influenza and what did it do

A

Containment and control based on:
1. Movement restrictions
2. Vaccination
3. Regionalisation and zoning
- Movement restriction NOT vaccination limited the spread of EI
- Zoning allowed some of the industry to trade and reduced losses to TB breeding
○ Gave horse owners rules for moving horses
○ Financially crippling for the racing and performance and pleasure horse industry within the red zone

68
Q

Where are the 8 main areas for controlling zoonotic disease

A
  1. Quarantine - national, regional and local
  2. Eradication of pathogens from flocks and herds
  3. Investigation, reporting and control of disease outbreaks
  4. Optimal production systems
  5. Control on marketing
  6. Control on feed sources
  7. Care and speed in sale transport
  8. Processing of food
69
Q

What are the 4 ways quality control is conducted in food to prevent zoonoses

A

1) meat inspection
- Severely diseased animals not slaughtered
- Mildly diseased animal slaughtered last
- Condemnation of specific sections of carcass
2) Pasteurization
3) inspection and grading of eggs
4) quality control in processing such as milk
- Cell counts to detect subclinical mastitis
- Bacterial cell counts and microbiological culture
- Detection of faecal contamination and of poor hygiene of milking lines
- Pasteurisation