Necrosis Flashcards
what is the definition of necrosis?
a condition of cell death thru injury of diseases, especially ina localized area of the body
whatv poart of the cell goes under digestion?
cytoplasm
What does the lysosome of the necrotic cell release?
lysosomal enzymes
what is coagulative necrosis?
implies the preservation of basic outline of the coagulated cell for period of at some days
what 3 things is necrosis characterized by?
a. denature of cyto plasmic proteins
b. break down of cell organelles
c. cell swelling
what is white infartion?
single blood supply
what is red infarction?
dual blood supply
what is liquefactive necrosis?
complete digestion of cells resulting in transformation of tissue into a liquid viscous mass
what is an example of liquefactive necrosis?
ischemic stroke of the brain
wha t is casseous necrosis?
amorphous granular debris seemingly composeed of fragmanted coagulated cells
what is amorphous granular debris?
enclosed within a distictive site inflammatory border known as granulomatous reaction
what does granuloma mean?
collection of immune cells that are trying to get rid of a foreign substance
what are examples of casseous necrosis?
TB and leprosy
what is gummatous necrosis?
develops only in syphilis
death of tissue is caused by treponema pallidum
usually acquired by sexual transmission
what is primary syphilus?
single chancre
what is secondary syphilus?
involves skin usually hands and feet
what is tertiary syphilus?
involves the aorta 80-85% of the time years later
and involves the CNS 5-10% of the time
What part of the spine does tertiary effect?
the posterior columns
what name does it receive when effecting the posterior columns?
tabes dorsalis
what is the name when the grey matter is atrophied?
general paesis
aka general paresis of insane
what are characteristics of Zenkers necrosis?
glassy waxy necrosis of the skeletal muscle
what is zenker’s necrosis (the disease) called?
typhiod fever
how do you contract zenkers necrosis?
salmonella bacteria
can also be caused by a snake bite
what is fat necrosis?
necrosis of the adipose tissue
characterized by small quantities of soap bubbles
where does fibriniod necrosis occur?
in the walls of blood vessels when edothelial cells and smotth muscle cells are injured/dying
what is an example of fibrinoid necrosis?
Aschoff’s nodes; seen in rhuematic fever
what is gangrene necrosis characterized by?
anaerobic bacterial metabolism
what causes dry gangrene ischemia?
lack of oxygen supplied to an organ or tissue
dry gangrene in the distal parts of the body is known as?
systemic sclerosis
what is atherosclerosis?
Buerger’s disease
affects nerves and veins not arteries
caused by smoking
what is dry gangrene diabetes mellitus?
obliteration of the distal small vessels
what is wet gangrene?
phagocytic cells break down the necrotoc debris and produce some liquefaction
what causes wet gangrene?
anaerobic bacteria
clostridium perfringes and bacillus fusiform
Wet gangrene in the distal parts of the fingers in known as?
polyarteritis nodosa
what causes intestinal gangrene?
anaerobic bacteria
what is gas gangrene?
bacterial infection that produces gas within tissue
common inthe military
what causes gas gangrene?
clostridium perfrimges
anaerobic streptoccocci
