Chapter 02: Cell Derived Mediators

Question 1

where is NO produced?

Answer 1

produced by endothelial cells of blood vessels

Question 2

what is the Fx of nitric oxide

Answer 2

vasodilator

causes smooth muscle to relax

Question 3

what does NO inhibit?

Answer 3

cellular inflammation

inhibits adhesion of WBC’s to endothelial cells (pavementing)

Question 4

what are eicosinoids?

Answer 4

arachadonic acid metabolites from phospholipid bi-layer

Question 5

where are eicosoniods derived from?

Answer 5

AA

Question 6

what cells produce eicosiniods?

Answer 6

all leukocytes and Mast cells

Question 7

what two enzyme mediated pathway does AA pass thru to produce prostiglandins and thromboxanes?

Answer 7

cyclooxygenase and lipooxygenase

Question 8

what is the fx of PGE2?

Answer 8

vasodilation and increase permeability

Question 9

what is PGE2 associated with controlling?

Answer 9

controlling inflammation, pain, and fever

Question 10

what is another role of PGE2 in females?

Answer 10

promotes uterine contravtion & cervix relaxation

Question 11

what cell(s) produce PGD2?

Answer 11

mast cells

Question 12

what does PGI2 induce?

Answer 12

induces bronchiospasm (asthma)

hyperalgesia

Question 13

what does PGD2 inhibit?

Answer 13

hair grwoth

Question 14

where is PGI2 produced?

Answer 14

is released by healthy endothelial cells

Question 15

what is the fx of PGI2 on blood vessels?

Answer 15

Inhibits platelet aggreation and causes vasodilation

Question 16

What is the fx of PGF2?

Answer 16

induce labor or cause abortion