Nagi's 5/6th Lecture BLOOD

Question 1

Why the pathological conditions that effects the platelets do not effects the coagulation although the platelets are so important to the coagulation process

Answer 1

Because to have a pathological condition that effects the coagulation the platelets count needs to be less than 10,000 which never happens but less than 50,000 is enough to make a platelets pathological condition

Question 2

Which substance is used in the blood banks to prevent the clotting of the blood and what does it do?

Answer 2

Citrate and it does deionization

Question 3

What does the oxalate do to the blood in the invitro

Answer 3

It do Ca precipitation

Question 4

What we can use to prevent clotting invitro

Answer 4

Oxalate
Citrate
Wax
Silicon

Question 5

Does the heparin works in invivo and invitro or not

Answer 5

Yes it does in both

Question 6

Does the warferin(dicumarol) or invivo or invitro

Answer 6

Invivo only

Question 7

What is the antidote or heparin

Answer 7

Protamine sulphate

Question 8

What is the antidote of warferin

Answer 8

It is vit K

Question 9

What we can do in the case that we gave the patient an heparin and warferin but it was the wrong call

Answer 9

We do a FREAH blood transfusion

Question 10

What does the vitamin K deficiency do to the hemostasis

Answer 10

It prolongs the coagulation time because it effects the formation of the prothrombin group (1972)

Question 11

What are the causes of the vit K deficiency

Answer 11

Warferin 
Newborn (no normal flora )
Excess or broad spectrum antibiotics 
Less fat absorption 
Liver disease

Question 12

What is the hemophilia

Answer 12

Sex linked recessive disease that linked to the X chromosome cause defect in either factor 8 nor 9 nor 11

Question 13

What happens to the bleeding and coagulation time in the hemophilia

Answer 13

The bleeding time is normal but the coagulation is prolonged

Question 14

What are the possible platelets defects

Answer 14

Thrombocytopanic (count less than 50,000)

Thromoboasthenic (defects in the collagen receptor)

Question 15

What is the most important symptom in the purpura

Answer 15

Petichea

Question 16

What happens to the bleeding and coagulation time in the platelets defects

Answer 16

Bleeding time is prolonged but the coagulation is normal

Question 17

What are the causes of the excessive clot formation

Answer 17

Slow blood flow:
Like after operation or baby delivery
That is why we make the patients to walk after the surgeries

Atherosclerosis:
Due to the rough endothelium

Question 18

What are the cases of excessive bleeding and clot formation

Answer 18

When a fetus die in his mothers uterus his tissues starts to degrade and forming a clots and due that all the coagulation factors are used on the bady which will left the mother in excessive bleeding .

If we are having a necrosis in any tissue without removing the dead tissues the will do as the baby’s tissues did

Question 19

What is the normal time of the bleed time test

Answer 19

3 min max

Question 20

What is the normal time for the

Whole blood coagulation time test

Answer 20

10 min max

Question 21

What is the activated partial thromboplastin test and
why we use it
Its normal rate

Answer 21

It is a coagulation test
We use it to see the coagulation in the intrinsic pathway
Its normal rate 40 sec

Question 22

What is the prothrombin time
test and
why we use it
Its normal rate

Answer 22

It is used for coagulation
To see the extrinsic pathway
Normal time 14 sec

Question 23

What is the test that used to detect vit k deficiency

Answer 23

It is prothrombin time

Question 24

What is the test that used to detect hemophilia

Answer 24

We use two test first one is activate partial blood test if the coagulation time is prolonged it means it is either k deficiency or hemophilia
So we do the prothrombin blood test if it was normal it means it is hemophilia