Nagi's 3rd Lecture BLOOD Flashcards
DNA nuclic acids
Good CAT cytosine Guanine thymine Adenine
What is thr difference between megaloblast
And megalocyst
The megalocyst has no nucleus
What is the name of the anemia that caused lack of B12 or B9
Megaloblastic anemia
What are the properties of megaloblastic anemia
Nermochromic
Macro cystic
Less numbers
Less life spam
What is the name of the carries protein of the B12
Transcublamin 2
Where is the b12 absorbed in the intestine and which bile it needs
In thr lower ilium qns it needs pancreatic bile
What does the iron needs to get absorbed
HCL
Vit C
Which beta globulin carry the iron in the blood
Transferrin
In which form the iron is stored
Ferritin
What is the main regulator iron absorption hormone and from where it is produce
Hepecidin
What does the hepecidin do
It is an inhibitor of iron absorption When it is high it Decreases the number of feropoitin Decrease releasing of macrophages that breakdown RBCs Decrease iron releases form the liver
Why does the infection cause anemia
Because it stimuli the hepecidin
What are the symptoms of the heomosidrosis
Skin pigmentation and pancreas damage cause prozen diabites
Liver cirrhosis
Testicle
Heart brain damage
What are the causes that prevent iron absorption
Acholrhydria (no HCL) Dueduneum disease Excess 1- ca++ 2- tea or coffee 3- phytic acid بالبر و القمع بقشرو
What is the worm that cause iron deficiency
Ankylostome
What is the RBCs number that we can call it anemia in males
4.5 million/mm3
What is the RBCs number that we can call it anemia in females
3.9 million/mm3
What is the amount of the HP that we call the person has anemia
Male and female
2.5g less the maximum in normal
Males 13.5g/dl
Female 11.5g/dl
What is the characteristics of the iron deficiency anemia
Microcytic
Hypochromic
What are intrinsic defects that leads to hemolytic anemia
1- in membrane Inhibitory sphero cytosis 2- HP shape Sickle shaped anemia 3- glucose-6-phosphate dehydrogenase enzyme deficiency البقوليات بتساعد في تكسير الانزيم
What are the extrinsic defects that cause hemolytic anemia
ABCD Antibodies. difference blood type Bacterial toxins Chemical positions like snakes Drugs as side effect